Cholinergic-glutamatergic interactions in visual recognition memory of rhesus monkeys
| Autor: | Thomas G. Aigner, Nobuya Matsuoka |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.drug_class Scopolamine Glutamic Acid chemistry.chemical_compound Glutamatergic Cognition Memory Parasympathetic Nervous System medicine Animals Neurotransmitter Dose-Response Relationship Drug General Neuroscience Memoria Parasympatholytics Muscarinic antagonist Receptor antagonist Macaca mulatta Dizocilpine chemistry NMDA receptor Cholinergic Female Dizocilpine Maleate Psychology Excitatory Amino Acid Antagonists Neuroscience medicine.drug |
| Zdroj: | NeuroReport. 7:565-568 |
| ISSN: | 0959-4965 |
| Popis: | Administration of either a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801 (dizocilpine), or a muscarinic antagonist, scopolamine, produces dose-related impairments in performance of a visual recognition memory task, delayed non-matching to sample (DNMS) with lists of 20 symbols, in rhesus monkeys. In the present study, low doses of these two drugs, which were ineffective when given alone, significantly impaired performance when given in combination. Moreover, the effect was greater than additive, indicating a synergistic interaction. These results suggest that interactions between cholinergic and glutamatergic systems play an important role in regulation of visual recognition memory. |
| Databáze: | OpenAIRE |
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