The solubilization of some local anaesthetic esters of p-aminobenzoic acid by lysophosphatidylcholine

Autor:	L. Saunders, M J Hunt
Rok vydání:	1975
Předmět:	Pharmacology chemistry.chemical_classification Magnetic Resonance Spectroscopy Chromatography Local anaesthetic Lysophosphatidylcholines Pharmaceutical Science Esters Nuclear magnetic resonance spectroscopy chemistry.chemical_compound Lysophosphatidylcholine Hydrocarbon Solubility chemistry P-Aminobenzoic acid Solubilization Organic chemistry Aminobenzoates lipids (amino acids peptides and proteins) Anesthetics Local
Zdroj:	Journal of Pharmacy and Pharmacology. 27:119-124
ISSN:	2042-7158 0022-3573
Popis:	The solubilization by lysophosphatidylcholine (LPC) of three n-alkyl esters of p-aminobenzoic acid has been studied. These esters have a local anaesthetic action. Quantitative studies show that the amount of compound solubilized is proportional to the LPC concentration and that solubilization increases in the order ethyl, n-propyl and n-butyl ester. 100MHz nmr studies indicate that the local anaesthetic esters are solubilized in the hydrocarbon interior of the LPC.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93188661deb773aba851895b6b632487 https://doi.org/10.1111/j.2042-7158.1975.tb09419.x Zobrazit plný text záznamu Plný text