Association of brain amyloidosis with the incidence and frequency of neuropsychiatric symptoms in ADNI: a multisite observational cohort study
| Autor: | Triet Do, Naira Goukasian, Tamineh Romero, Jonathan Grotts, Daniel R. Bateman, Jenna Rae Groh, Liana G. Apostolova, Kristy S. Hwang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Amyloid Alzheimer’s disease (AD) Behavioral Symptoms Neuropsychiatric Symptoms (NPS) Irritability 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Risk Factors Mild Cognitive Impairment (MCI) Internal medicine Surveys and Questionnaires mental disorders medicine Dementia Humans Apathy Cognitive Dysfunction Longitudinal Studies Mild cognitive impairment (MCI) Cognitive decline Aged Original Research Aged 80 and over 030214 geriatrics business.industry Amyloidosis Alzheimer’s Disease Neuroimaging Initiative (ADNI) General Medicine medicine.disease Magnetic Resonance Imaging 3. Good health Neurology Case-Control Studies Positron-Emission Tomography Disease Progression Anxiety medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | ObjectiveTo investigate the relationship between amyloid burden and frequency of existing and incidence of new neuropsychiatric symptoms (NPS) in elderly with and without cognitive decline.Methods275 cognitively normal controls (NC), 100 subjective memory complaint (SMC), 559 mild cognitive impairment (MCI) and 143 Alzheimer’s disease dementia subjects from the Alzheimer’s Disease Neuroimaging Initiative received (18F)-florbetapir positron emission tomography (PET) scans. Yearly neuropsychiatric inventory (Neuropsychiatric Inventory (NPI)/NPI-Questionnaire) data were collected from the study partners at each visit. Mean standard uptake volume ratios (SUVR) normalised to whole cerebellum were obtained. Positive amyloid PET scan was defined as mean SUVR ≥1.17. Fisher’s exact test was used to compare frequency and incidence between amyloid positive and amyloid negative subjects. Survival analyses were used to estimate of neuropsychiatric symptoms (NPS) between amyloid positive and amyloid negative subjects. Survival analyses were used to estimate hazard ratios for developing the most common NPS by amyloid status.ResultsNo differences in NPS frequency were seen between amyloid positive and amyloid negative NC, SMC, MCI or dementia groups. MCI subjects with amyloid pathology however tended to have greater frequency x severity (FxS) of anxiety, hallucinations, delusions, apathy, disinhibition, irritability, aberrant motor behavior, and appetite, but not agitation, depression, night-time disturbances, or elation. MCI subjects with amyloid pathology were at greater risk for developing apathy, anxiety and agitation over time. Baseline presence of agitation and apathy and new onset agitation, irritability and apathy predicted faster conversion to dementia among MCI subjects.ConclusionsAmyloid pathology is associated with greater rate of development of new NPS in MCI. Anxiety and delusions are significant predictors of amyloid pathology. Agitation, irritability and apathy are significant predictors for conversion from MCI to dementia. |
| Databáze: | OpenAIRE |
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