Short-term effects of a combined nutraceutical of insulin-sensitivity, lipid level and indexes of liver steatosis: a double-blind, randomized, cross-over clinical trial
| Autor: | Angelo Parini, Claudio Borghi, Arrigo F G Cicero, Martina Rosticci, Martino Morbini, Elisa Grandi, Riccardo Urso |
|---|---|
| Přispěvatelé: | Cicero, Arrigo FG, Rosticci, Martina, Parini, Angelo, Morbini, Martino, Urso, Riccardo, Grandi, Elisa, Borghi, Claudio |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Berberine Lipoproteins Liver steatosis Medicine (miscellaneous) Hyperlipidemias Clinical nutrition Overweight Placebo Gastroenterology Time law.invention chemistry.chemical_compound Insulin resistance Double-Blind Method Randomized controlled trial law Internal medicine medicine Humans Insulin Lipoprotein Aged Insulin-sensitivity Cross-Over Studies Nutrition and Dietetics Cholesterol business.industry Research Tocotrienols Chlorogenic acid Middle Aged medicine.disease Lipids Crossover study Fatty Liver Treatment Outcome chemistry Liver steatosi Dietary Supplements Female lipids (amino acids peptides and proteins) Nutraceutical Insulin Resistance medicine.symptom business Lipid Accumulation Product |
| Zdroj: | Nutrition Journal |
| ISSN: | 1475-2891 |
| Popis: | Background: Overweight subjects easily develop alterations of the glucose and lipid metabolism and are exposed to an increased cardiometabolic risk. This condition is potentially reversible through the improvement of dietary and behavioural habits. However, a well-assembled nutraceutical would be a useful tool to better improve the metabolic parameters associated to overweight and insulin resistance. Methods: To evaluate the effect of a combined nutraceutical containing berberine, chlorogenic acid and tocotrienols, we performed a double blind, cross-over designed trial versus placebo, in 40 overweight subjects with mixed hyperlipidaemia. After the first 8 weeks of treatment (or placebo), patients were asked to observe a 2-week washout period, and they were then assigned to the alternative treatment for a further period of 8 weeks. Clinical and laboratory data associated to hyperlipidaemia and insulin resistance have been obtained at the baseline, at the end of the first treatment period, after the washout, and again after the second treatment period. Results: Both groups experienced a significant improvement of anthropometric and biochemical parameters versus baseline. However, total cholesterol, LDL cholesterol, triglycerides, non-HDL cholesterol, fasting insulin, HOMA-IR, GOT and Lipid Accumulation Product decreased more significantly in the nutraceutical group versus placebo. Conclusions: This combination seems to improve a large number of metabolic and liver parameters on the short-term in overweight subjects. Further studies are needed to confirm these observations on the middle- and long-term. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|