NMR spectroscopy and surface tension measurements applied to the study of self-association of casopitant mesylate, a novel NK1 antagonist
| Autor: | Stefania Beato, Zadeo Cimarosti, Andrea Casazza, Stefano Provera, Carla Marchioro, Grazia Caivano, Lucilla Turco |
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| Rok vydání: | 2010 |
| Předmět: |
Magnetic Resonance Spectroscopy
Surface Properties Sodium Chemistry Pharmaceutical Clinical Biochemistry Analytical chemistry Pharmaceutical Science chemistry.chemical_element Micelle Piperazines Analytical Chemistry Surface tension Neurokinin-1 Receptor Antagonists Piperidines Drug Discovery Casopitant medicine Humans Technology Pharmaceutical Piperazine Spectroscopy Micelles Chemical shift Temperature Nuclear magnetic resonance spectroscopy Hydrogen-Ion Concentration chemistry Models Chemical Critical micelle concentration Drug Design Proton NMR Thermodynamics medicine.drug |
| Zdroj: | Journal of pharmaceutical and biomedical analysis. 54(1) |
| ISSN: | 1873-264X |
| Popis: | The aggregation behaviour of casopitant mesylate, a new NK1 antagonist drug, was investigated by means of NMR spectroscopy and surface tension measurements. The critical micelle concentration (CMC) in glycine buffer at pH 3.5 was determined by analyzing the (1)H NMR chemical shifts variation and the surface tension in function of the concentration in a series of solutions. The temperature dependence of the CMC was also evaluated by NMR spectroscopy as well as the thermodynamic parameters contributing to the aggregation discussed. Surface tension measurements were conducted as well in the formulation conditions, e.g. in the presence of sodium chloride. |
| Databáze: | OpenAIRE |
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