Functional Connectivity between Hemispheres and Schizophrenic Symptoms: A Longitudinal Study of Interhemispheric EEG Coherence in Patients with Acute Exacerbations of Schizophrenia
| Autor: | Tatsuya Nagasawa, Yoshifumi Koshino, Mitsuru Kikuchi, Masato Higashima, Tsutomu Takeda |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Longitudinal study Statistics as Topic Electroencephalography Audiology Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Brief Psychiatric Rating Scale medicine Humans Functional disconnection Diagnosis Computer-Assisted Longitudinal Studies Psychiatry medicine.diagnostic_test Functional connectivity Brain General Medicine Coherence (statistics) Middle Aged medicine.disease 030227 psychiatry Neurology Frontal lobe Schizophrenia Female Neurology (clinical) Psychology 030217 neurology & neurosurgery |
| Zdroj: | Clinical EEG and Neuroscience. 37:10-15 |
| ISSN: | 2169-5202 1550-0594 |
| Popis: | To clarify whether interhemispheric electroencephalogram (EEG) coherence reflecting functional connectivity between the two cerebral hemispheres can change in a symptom-dependent manner in schizophrenia, we measured resting EEG and symptom severity twice at an average interval of 32.7 days during the course of treatment in 15 patients hospitalized for acute exacerbations of schizophrenia. Symptom severity was estimated quantitatively by means of the Brief Psychiatric Rating Scale (BPRS). Correlation analysis showed that increases in the beta-band coherence for frontal electrode pairs during the treatment were associated with improvement in the total score and the score on the positive subscale of BPRS. This result suggests that functional disconnection between the left and right frontal lobes may be related to the generation of psychotic symptoms and can normalize following antipsychotic treatment. |
| Databáze: | OpenAIRE |
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