Clinical, microscopic, and molecular aspects of canine leproid granuloma in the United States
| Autor: | Courtney Rand, Janet E Foley, T. L. Gross, Martha L. Needham, Amy Poland, Dori L. Borjesson |
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| Rok vydání: | 2002 |
| Předmět: |
0301 basic medicine
Surgical resection Male medicine.medical_specialty Pathology 040301 veterinary sciences Polymerase Chain Reaction law.invention Mycobacterium 0403 veterinary science 03 medical and health sciences Dogs law Cytology RNA Ribosomal 16S Complete regression Medicine Animals Dog Diseases Polymerase chain reaction Mycobacterium Infections Granuloma General Veterinary business.industry 04 agricultural and veterinary sciences Skin Diseases Bacterial Ribosomal RNA medicine.disease Prognosis 030104 developmental biology Histopathology Female business |
| Zdroj: | Veterinary pathology. 39(2) |
| ISSN: | 0300-9858 |
| Popis: | Leproid granulomas from seven dogs in the United States were evaluated. Gross characteristics included nodular and ulcerated dermal and subcutaneous lesions primarily on the caudal aspects of the pinnae and to a lesser extent on the muzzle, face, and forelimbs. In all except one dog, there was complete regression of the lesions within 6 months, either with no therapy or after surgical resection. Cytology or histopathology revealed pyogranulomatous inflammation with few to many acid-fast mycobacterial bacilli within macrophages. The organisms could not be cultivated in vitro. DNA sequencing of part of the 16S ribosomal RNA gene region revealed 99–100% homology among fragments from five of these dogs and fragments from dogs in the South Pacific. This syndrome occurs in dogs in North America and the prognosis is excellent, in contrast to the prognosis for rapid-growing or tuberculous mycobacteriosis. |
| Databáze: | OpenAIRE |
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