Selective transfer of cyclosporin to thoracic lymphatic systems by the application of lipid microspheres
| Autor: | Hiroshi Oka, Yutaka Mizushima, Akira Yanagawa, Keiyu Takano, Tomoko Saotome, Takemasa Nakagawa, Takashi Iwayama, Yoko Shoji |
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| Rok vydání: | 1989 |
| Předmět: |
Drug Carriers
Chemistry Organic Chemistry Pharmaceutical Science Biological Transport Cyclosporins Rats Inbred Strains Bioengineering Pharmacology Lipids Microspheres Dosage form Rats Lymphatic System Colloid and Surface Chemistry Lymphatic system Pharmacokinetics In vivo Oral administration Cyclosporin a Blood plasma Immunology Animals Distribution (pharmacology) Physical and Theoretical Chemistry |
| Zdroj: | Journal of Microencapsulation. 6:161-164 |
| ISSN: | 1464-5246 0265-2048 |
| DOI: | 10.3109/02652048909098016 |
| Popis: | To overcome some of the disadvantages of present cyclosporin A (CsA) therapy, lipid microspheres incorporating CsA (lipo-CsA) were designed and their selective transfer to thoracic lymphatic systems was evaluated in vivo. It was found that concentrations of CsA in lymph-ducts were about 46 times higher after 2h and 9-10 times higher after 3h following oral administration of lipo-CsA, compared with those of conventional CsA. The concentrations in plasma produced by lipo-CsA were also higher than those produced by conventional CsA. |
| Databáze: | OpenAIRE |
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