Attenuation of neuromotor deficits by natural antioxidants of Decalepis hamiltonii in transgenic Drosophila model of Parkinson's disease
| Autor: | Samaneh Reiszadeh Jahromi, Mohammad Haddadi, Saraf R. Ramesh, Thimmappa Shivanandappa |
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| Rok vydání: | 2014 |
| Předmět: |
Biology
Pharmacology Motor Activity medicine.disease_cause Decalepis hamiltonii Plant Roots Antioxidants Lipid peroxidation Superoxide dismutase Animals Genetically Modified chemistry.chemical_compound Paraquat medicine Animals chemistry.chemical_classification Reactive oxygen species Plant Extracts General Neuroscience fungi Neurotoxicity Parkinson Disease medicine.disease biology.organism_classification Circadian Rhythm Disease Models Animal Oxidative Stress chemistry Biochemistry Catalase biology.protein alpha-Synuclein Drosophila Lipid Peroxidation Reactive Oxygen Species Oxidative stress |
| Zdroj: | Neuroscience. 293 |
| ISSN: | 1873-7544 |
| Popis: | Oxidative stress is believed to be a major factor for the onset of Parkinson’s disease (PD). In this study, we have investigated oxidative status in transgenic Drosophila model of PD. Our results revealed elevated levels of reactive oxygen species (ROS) and lipid peroxidation (LPO) in A30P and A53T α-synuclein PD model flies compared to control. We have demonstrated for the first time the ameliorating potential of natural antioxidants characterized from the roots of Dh in A30P and A53T α-synuclein PD model flies. Feeding of transgenic flies with aqueous Dh root extract for 21 days significantly improved their climbing ability and circadian rhythm of locomotor activity which was associated with reduction in levels of ROS and LPO and enhancement in the activities of catalase (CAT) and superoxide dismutase (SOD). Dh protected against paraquat (PQ) sensitivity in α-synuclein transgenic flies and delayed the onset of PD-like symptoms which appears to be mediated by suppression of oxidative stress. |
| Databáze: | OpenAIRE |
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