Anabolic effects of leucine-rich whey protein, carbohydrate, and soy protein with and without β-hydroxy-β-methylbutyrate (HMB) during fasting-induced catabolism: A human randomized crossover trial
| Autor: | Anja Serena, Niels Møller, Jakob Hansen, Niels Jessen, Jens Otto Lunde Jørgensen, Ermina Bach, Bjørn Richelsen, Mogens Johannsen, Erik Jensen, Henrik Holm Thomsen, Andreas Buch Møller, Nikolaj Rittig |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Whey protein Anabolism Cell Cycle Proteins Critical Care and Intensive Care Medicine Ribosomal Protein S6 Kinases 90-kDa Glucagon Anabolic Agents Body Mass Index Young Adult 03 medical and health sciences Leucine Internal medicine Dietary Carbohydrates Valerates medicine Humans Phosphorylation Muscle Skeletal Soy protein Adaptor Proteins Signal Transducing Cross-Over Studies 030109 nutrition & dietetics Nutrition and Dietetics Catabolism business.industry TOR Serine-Threonine Kinases Fasting Phosphoproteins Crossover study Whey Proteins Endocrinology Soybean Proteins business Signal Transduction |
| Zdroj: | Rittig, N, Bach, E, Thomsen, H H, Møller, A B, Hansen, J, Johannsen, M, Jensen, E, Serena, A, Jørgensen, J O L, Richelsen, B, Jessen, N & Møller, N 2017, ' Anabolic effects of leucine-rich whey protein, carbohydrate, and soy protein with and without β-hydroxy-β-methylbutyrate (HMB) during fasting-induced catabolism: A human randomized crossover trial ', Clinical Nutrition, vol. 36, no. 3, pp. 697-705 . https://doi.org/10.1016/j.clnu.2016.05.004 |
| DOI: | 10.1016/j.clnu.2016.05.004 |
| Popis: | Summary Background Protein-rich beverages are widely used clinically to preserve muscle protein and improve physical performance. Beverages with high contents of leucine or its keto-metabolite β-hydroxy-β-methylbutyrate (HMB) are especially anabolic in muscle, but it is uncertain whether this also applies to catabolic conditions such as fasting and whether common or separate intracellular signaling cascades are involved. Objective To compare a specific leucine-rich whey protein beverage (LWH) with isocaloric carbohydrate- (CHO), soy protein (SOY), and soy protein +3 g HMB (HMB) during fasting-induced catabolic conditions. Design Eight healthy lean male subjects underwent four interventions (LWH, CHO, SOY, and HMB) using a randomized crossover design. Each trial included a 36 h fast and consisted of a 3 h basal fasting period and a 4 h ‘sipping' period. Results Forearm net balances of phenylalanine (NB phe , measure of net protein loss) improved for all groups (p Conclusion LWH and HMB have superior anabolic effects on muscle protein kinetics after 36 h of fasting, and LWH distinctly activates the mTOR pathway. These novel findings suggest that leucine-rich whey protein and/or HMB are specifically beneficial during fasting-induced catabolic conditions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|