Selective co-evolution of the D6STNFa microsatellite region with HLA class I and II loci
| Autor: | M. Kazemi, R. Meer, Arno R. van der Slik, R.F. Schipper, Payman Hanifi Moghaddam, P. Knijff, S.L.E. Lambooij, N. Pesonen, Pejman Hanifi Moghaddam, Albert Naipal, Marius J. Giphart |
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| Rok vydání: | 1998 |
| Předmět: |
Linkage disequilibrium
Genotype Denmark Immunology Locus (genetics) Human leukocyte antigen Minisatellite Repeats Biology Biochemistry Linkage Disequilibrium Evolution Molecular Random Allocation Genetic linkage HLA Antigens Genetics Immunology and Allergy Humans Allele Allele frequency Histocompatibility Antigens Class I Histocompatibility Antigens Class II General Medicine Microsatellite Microsatellite Repeats |
| Zdroj: | Tissue antigens. 52(3) |
| ISSN: | 0001-2815 |
| Popis: | We analyzed the HLA-A, -B, -DR and -DQ phenotypes and 12 microsatellite locus genotypes within and close to the major histocompatibility complex in a panel of 98 randomly selected, healthy, unrelated Dutch Caucasoid individuals. Allele frequencies and Hardy-Weinberg equilibrium (HWE) were calculated. Also, the linkage disequilibrium patterns between HLA and microsatellite loci were studied. The HLA-A, -B, -DR, -DQ and six microsatellite loci centromeric of the HLA-A showed HWE. In contrast, all microsatellites telomeric of the HLA-A showed deviation from HWE due to excess of homozygosity. Linkage disequilibrium analyses provided strong evidence that among the tested microsatellite loci only the alleles of the D6STNFa locus are in linkage disequilibrium with both HLA-B and -DR. Our results suggest that selection acting on the HLA genes includes the D6STNFa locus and linked genes. |
| Databáze: | OpenAIRE |
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