Release of Warfarin from Human Serum Albumin by Water‐soluble CdSe Nanotetrapods
| Autor: | Anindya Datta, Amritha Sajeevan, Tanuja Kistwal, Sucheta Banerjee |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
2019-20 coronavirus outbreak
Bleach Serum Albumin Human 02 engineering and technology 010402 general chemistry 01 natural sciences chemistry.chemical_compound Cadmium Compounds medicine Humans Particle Size Physical and Theoretical Chemistry Selenium Compounds Protein secondary structure Molecular Structure Ligand Water 021001 nanoscience & nanotechnology Human serum albumin Fluorescence Atomic and Molecular Physics and Optics 0104 chemical sciences Oleic acid Water soluble Solubility chemistry Nanoparticles 0210 nano-technology Nuclear chemistry medicine.drug |
| Zdroj: | ChemPhysChem. 21:2709-2714 |
| ISSN: | 1439-7641 1439-4235 |
| DOI: | 10.1002/cphc.202000292 |
| Popis: | Water soluble CdSe nanotetrapods are prepared by ligand exchange from organic-soluble ones. In order to achieve this, oleic acid, which is the capping agent for as prepared water-insoluble nanotetrapods, is exchanged with mercaptopropanoic acid (MPA). Shape and size of nanotetrapods are conserved upon ligand exchange. Ground state bleach recovery dynamics remain the same as well. However, they are completely non-emissive. These water-soluble nanotetrapods disrupt the secondary structure of Human Serum Albumin (HSA) and consequently, release warfarin bound to the protein. |
| Databáze: | OpenAIRE |
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