Alcohols for Skin Antisepsis at Clinically Relevant Skin Sites
| Autor: | Günter Kampf, Thomas Kohlmann, Peter Heisig, Mirja Reichel |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
medicine.medical_specialty medicine.drug_class Colony Count Microbial Skin flora Alcohol Clinical Therapeutics chemistry.chemical_compound Double-Blind Method Antiseptic Humans Medicine Pharmacology (medical) Prospective Studies Skin Pharmacology Ethanol integumentary system biology business.industry Chlorhexidine Isopropyl alcohol Middle Aged biology.organism_classification Surgery Infectious Diseases medicine.anatomical_structure chemistry Alcohols Anesthesia Anti-Infective Agents Local Forehead business After treatment medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 53:4778-4782 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.00582-09 |
| Popis: | The antiseptic efficacy of ethanol, isopropanol, and n -propanol at 60%, 70%, and 89.5% (all vol/vol) was analyzed after 2, 3, or 4 min of application to the forehead, back, and abdomen of 180 volunteers by the use of a standardized swab sampling method. Results of recolonization by the aerobic skin flora of the upper arms and backs of 20 volunteers were compared 72 h after treatment with 0.5%, 1%, or 2% chlorhexidine digluconate (CHG) in 89.5% n -propanol. The most effective alcohol at all skin sites was n -propanol, with a mean log 10 reduction of 1.82 after 2 min on the forehead. Efficacy against the aerobic flora of the forehead was mainly influenced by the type of alcohol ( P < 0.001), followed by the concentration ( P < 0.001) and the application time ( P = 0.006). Ethanol and isopropanol were significantly less effective (both P < 0.001). Alcohol supplemented with 0.5% or more CHG was significantly more effective than alcohol alone in the suppression of recolonization ( P < 0.05). An 89.5% solution of n -propanol was the most effective alcohol for the reduction of populations of aerobic skin flora. Its combination with CHG is appropriate whenever recolonization of the skin must be limited. Further studies are needed to determine the most effective concentration of CHG in n -propanol to provide the best protection against recolonization of the skin, e.g., for catheter site care. |
| Databáze: | OpenAIRE |
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