Peripheral blood CD34+ cell count reliably predicts autograft yield
| Autor: | Michael A. Quinn, Max Wolf, I Bertoncello, C. Seymour, J Gardyn, Surender Juneja, Henry Miles Prince, P Chapple, H Januszewicz, D. Venter, M Brettell |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Pathology
medicine.medical_specialty Cd34 cells medicine.medical_treatment CD34 Hematopoietic stem cell transplantation Peripheral blood mononuclear cell Transplantation Autologous Predictive Value of Tests medicine Humans Prospective Studies Progenitor cell Transplantation business.industry Graft Survival Hematopoietic Stem Cell Transplantation Hematology Hematopoietic Stem Cells Prognosis Peripheral blood Blood Cell Count Linear correlation Nuclear medicine business |
| Zdroj: | Bone marrow transplantation. 22(2) |
| ISSN: | 0268-3369 |
| Popis: | A reliable measure to predict peripheral blood progenitor cell (PBPC) autograft CD34+ cell content is required to optimize the timing of PBPC collection. We prospectively examined the peripheral blood (PB) CD34+ cell count in 59 consecutive patients with various malignancies and analyzed the correlation between the PB CD34+ cell count and various parameters in the PBPC autograft. Two hundred and thirty-five collections were performed with a median of 4.0 collections per patient (range, 2-10). The median PB CD34+ cell count at the time of collection was 39 x 10(6)/1 (range, 0.0-285.6). The PBPC autograft parameters measured were the CD34+ cell, colony-forming unit granulocyte-macrophage (CFU-GM) and mononuclear cell (MNC) content. There was a strong linear correlation between PB CD34+ cells/l and autograft CD34+ cells/kg (r = 0.8477). The correlation with CFU-GM/kg (r = 0.5512) was weaker. There was no correlation between autograft CD34+ cells/kg and PB WBC (r= 0.0684), PB MNC (r = 0.1518) or PB platelet count (r = 0.2010). At our institution we aim to obtain a minimum of 0.5 x 10(6) CD34+ cells/kg with each day of collection. We demonstrate that such a collection can be reliably obtained if the PB CD34+ cell count exceeds 5.0 x 10(6)/l. |
| Databáze: | OpenAIRE |
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