The Serotonergic Mechanisms Are Not Involved in the Inhibitory Effect of Captopril on Rat Platelet Aggregation
| Autor: | Buczko W, E. Chabielska, B Malinowska, M.H. Pietraszek |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Blood Platelets
Male Serotonin medicine.medical_specialty Captopril Platelet Aggregation Platelet aggregation medicine.medical_treatment Serotonergic Physiology (medical) Internal medicine medicine Coagulopathy Animals Platelet cardiovascular diseases Chemotherapy Chemistry Rats Inbred Strains Hematology medicine.disease In vitro Rats Adenosine Diphosphate Endocrinology Collagen Ketanserin hormones hormone substitutes and hormone antagonists circulatory and respiratory physiology medicine.drug |
| Zdroj: | Pathophysiology of Haemostasis and Thrombosis. 20:48-53 |
| ISSN: | 1424-8840 1424-8832 |
| DOI: | 10.1159/000216104 |
| Popis: | The influence of captopril on blood platelet aggregation and on serotonergic mechanisms in blood platelets were studied. In rats pretreated with captopril (10.0 mg/kg p.o.) platelet aggregation induced by ADP and collagen was significantly reduced. In vitro this drug had no inhibitory effect. Besides, captopril did not change the amplifying effect of serotonin on platelet aggregation. Captopril also had no influence on the uptake and storage of 5-hydroxytryptamine by rat blood platelets. These results show that serotonergic mechanisms are not involved in the suppressive effect of captopril on platelet aggregation. |
| Databáze: | OpenAIRE |
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