Predicting Long-Term Hepatocellular Carcinoma Response to Transarterial Radioembolization Using Contrast-Enhanced Ultrasound: Initial Experiences
| Autor: | John R. Eisenbrey, Allison Tan, Patrick O'Kane, Kevin Anton, Lauren J Delaney, Jesse Civan, Flemming Forsberg, Priscilla Machado, Andrej Lyshchik, Colette M. Shaw, Ji-Bin Liu, Mohamed Tantawi, Corinne E. Wessner |
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| Rok vydání: | 2021 |
| Předmět: |
Carcinoma
Hepatocellular Acoustics and Ultrasonics Biophysics Contrast Media Pilot Projects Transarterial Radioembolization Article 03 medical and health sciences 0302 clinical medicine Vascularity Humans Medicine Yttrium Radioisotopes Radiology Nuclear Medicine and imaging Ultrasonography Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Liver Neoplasms Ultrasound Magnetic resonance imaging medicine.disease Treatment Outcome Response Evaluation Criteria in Solid Tumors 030220 oncology & carcinogenesis Hepatocellular carcinoma 030211 gastroenterology & hepatology medicine.symptom Tomography X-Ray Computed Nuclear medicine business Perfusion Contrast-enhanced ultrasound |
| Zdroj: | Ultrasound Med Biol |
| ISSN: | 0301-5629 |
| DOI: | 10.1016/j.ultrasmedbio.2021.05.006 |
| Popis: | Conventional cross-sectional imaging done shortly after radioembolization of hepatocellular carcinoma (HCC) does not reliably predict long-term response to treatment. This study evaluated whether quantitative contrast-enhanced ultrasound (CEUS) can predict the long-term response of HCC to yttrium-90 (Y-90) treatment. Fifteen patients underwent CEUS at three time points: immediately following treatment and 1 and 2 wk post-treatment. Response 3–6 mo after treatment was categorized on contrast-enhanced magnetic resonance imaging by two experienced radiologists using the Modified Response Evaluation Criteria in Solid Tumors. CEUS data were analyzed by quantifying tumor perfusion and residual fractional vascularity using time–intensity curves. Patients with stable disease on magnetic resonance imaging had significantly greater fractional vascularity 2 wk post-treatment (65.15%) than those with partial or complete response (13.8 ± 9.9%, p = 0.007, and 14.9 ± 15.4%, p = 0.009, respectively). Complete responders had lower tumor vascularity at 2 wk than at post-operative examination (–38.3 ± 15.4%, p = 0.045). Thus, this pilot study suggests CEUS may provide an earlier indication of Y-90 treatment response than cross-sectional imaging. |
| Databáze: | OpenAIRE |
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