Longitudinal airway remodeling in active and past smokers in a lung cancer screening population
| Autor: | Jan Tremper, Torben Buschulte, Erna Motsch, Mila Trauth, Monika Eichinger, Stefan Delorme, Bertram Jobst, Anke Trotter, Hans-Ulrich Kauczor, Marie-Luise Groß, Nikolaus Becker, Oliver Weinheimer, Mark O. Wielpütz |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Population Lumen (anatomy) Bronchi 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Radiology Nuclear Medicine and imaging education Early Detection of Cancer Aged education.field_of_study Smokers business.industry Smoking General Medicine Middle Aged respiratory tract diseases Exact test 030220 oncology & carcinogenesis Cardiology Mann–Whitney U test Smoking cessation Airway Remodeling Female Radiology Analysis of variance business Airway Tomography X-Ray Computed Lung cancer screening |
| Zdroj: | European radiology. 29(6) |
| ISSN: | 1432-1084 |
| Popis: | To longitudinally investigate smoking cessation-related changes of quantitative computed tomography (QCT)–based airway metrics in a group of heavy smokers. CT scans were acquired in a lung cancer screening population over 4 years at 12-month intervals in 284 long-term ex-smokers (ES), 405 continuously active smokers (CS), and 31 subjects who quitted smoking within 2 years after baseline CT (recent quitters, RQ). Total diameter (TD), lumen area (LA), and wall percentage (WP) of 1st–8th generation airways were computed using airway analysis software. Inter-group comparison was performed using Mann-Whitney U test or Student’s t test (two groups), and ANOVA or ANOVA on ranks with Dunn’s multiple comparison test (more than two groups), while Fisher’s exact test or chi-squared test was used for categorical data. Multiple linear regression was used for multivariable analysis. At any time, TD and LA were significantly higher in ES than CS, for example, in 5th–8th generation airways at baseline with 6.24 mm vs. 5.93 mm (p |
| Databáze: | OpenAIRE |
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