Tuberculosis in Children in a Pediatric Hospital in Mexico
| Autor: | Mercedes Macías Parra, Hugo Juárez Olguín, Monica Punzo Soto, Napoleón González Saldaña, José Iván Castillo Bejarano, Francisca Trujillo Jiménez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Tuberculosis Adolescent Tuberculin Disease Tuberculosis Lymph Node Sensitivity and Specificity Article Cohort Studies Virology Internal medicine Epidemiology Biopsy medicine Humans Pathology Molecular Child Coloring Agents Lymph node Mexico Tuberculosis Pulmonary Retrospective Studies Lung medicine.diagnostic_test business.industry Mycobacterium tuberculosis medicine.disease Hospitals Pediatric Infectious Diseases medicine.anatomical_structure Child Preschool Tuberculosis Meningeal Parasitology Female business Cohort study |
| Zdroj: | Am J Trop Med Hyg |
| Popis: | Tuberculosis (TB) remains a global problem and a diagnostic challenge, especially in pediatrics. The aim of this study was to describe the clinical, microbiological, radiological, and histopathological data of TB in children. A 7-year retrospective and descriptive cohort study that included 127 patients under 18 years of age with diagnosis of active TB was conducted from 2011 to 2018 in a pediatric hospital. Tuberculosis was microbiologically confirmed using Ziehl–Neelsen (ZN) staining, culture or polymerase chain reaction (PCR) in a total of 94 (74%) cases. Thirty-three cases were defined as probable TB based on tuberculin skin test result and epidemiological evaluation. The TB forms found were lymph node (39.3%), bone (15.7%), lung (13.6%), and meningeal TB (8.6%). The most common symptoms were fever (48.8%) and adenopathy (45.6%). History of contact was established in 34.6%. Positive ZN staining (sensitivity 30%) and culture (sensitivity 37%) were found in 29% and 37.7% of subjects, respectively. About 64.5% depicted abnormal chest X-ray. Xpert MTB/RIF® (PCR) was positive in 9.4% and biopsy was compatible in 52.7% of these samples. It is fundamental to have laboratory and epidemiological evaluation that support the diagnosis of the disease in children and thus, define its management; since, in most cases, early microbiologic confirmation is lacking. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|