Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge
| Autor: | Li Zhang, B S Bender, T Croghan, Parker A. Small |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
T-Lymphocytes
Transgene Immunology Orthomyxoviridae Virulence Mice Transgenic Major histocompatibility complex medicine.disease_cause Virus Mice Orthomyxoviridae Infections Influenza A virus medicine Animals Immunology and Allergy Lung biology Histocompatibility Antigens Class I Articles T lymphocyte biology.organism_classification Survival Analysis Virology biology.protein beta 2-Microglobulin CD8 |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.175.4.1143 |
| Popis: | To investigate the role of CD8+ T lymphocytes in recovery from influenza pneumonia, we used transgenic mice either homozygous (-/-) or heterozygous (+/-) for beta 2-microglobulin (beta 2-M) gene disruption. These mice lack major histocompatibility complex-restricted class I (CD8+) T cells. We found that after challenge with a nonlethal influenza virus, the beta 2-M (-/-) mice had significantly delayed pulmonary viral clearance. Furthermore, after challenge with a more virulent influenza virus, the beta 2-M (-/-) mice had a significantly higher mortality rate than did control mice. Thus, CD8+ T cells are important in recovery from virulent influenza infections, but other host defense mechanisms can clear the respiratory tract of more benign infections. |
| Databáze: | OpenAIRE |
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