Kisspeptin and LH pulsatile temporal coupling in PCOS patients
| Autor: | Adam Czyzyk, Agnieszka Podfigurna, Alessandro D. Genazzani, Blazej Meczekalski, Krzysztof Katulski |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
LH medicine.medical_specialty Kisspeptin Endocrinology Diabetes and Metabolism media_common.quotation_subject Pulsatile flow 030209 endocrinology & metabolism 03 medical and health sciences Young Adult 0302 clinical medicine Endocrinology Internal medicine medicine PCOS Humans Pulses Testosterone Menstrual cycle Menstrual Cycle Menstruation Disturbances media_common Kisspeptins 030219 obstetrics & reproductive medicine Estradiol business.industry Algorithms Disease Progression Female Hormones Luteinizing Hormone Polycystic Ovary Syndrome Polycystic ovary Prolactin Original Article business Luteinizing hormone hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Endocrine |
| Popis: | Purpose To evaluate the temporal coupling between spontaneous kisspeptin and luteinizing hormone (LH) pulsatile releases in polycystic ovary syndrome (PCOS) patients. Methods We examined 71 patients diagnosed with PCOS. A 2 h pulsatility study was performed to evaluate serum kisspeptin and LH pulse frequency and concentration, sampled every 10 min; baseline follicle-stimulating hormone (FSH), estradiol (E2), prolactin (PRL), cortisol, 17-hydroksy-progesterone (17OHP), testosterone (T), free testosterone index (FTI, and insulin levels were also measured. Detect and Specific Concordance (SC) algorithms were used to evaluate the temporal coupling associations between spontaneous episodic secretion of kisspeptin and LH. Results All PCOS patients demonstrated LH and kisspeptin pulsatile secretions. When the SC index was calculated across the sample of PCOS patients (n = 71), no temporal coupling was observed between kisspeptin and LH pulses. When PCOS patients were subdivided according to their menstrual cyclicity, oligomenorrheic patients demonstrated elevated kisspeptin pulse frequency. Additionally, the SC index reveled a temporal coupling between kisspeptin and LH secretory peaks only in eumenorrheic patients (n = 30, intermenstrual interval 45 days) did not demonstrate temporal coupling between kisspeptin and LH secretory peaks. Conclusions The study of the endogenous kisspeptin and LH pulsatile release revealed the temporal coupling of kisspeptin with LH secretory pulses only in eumenorrheic. This data supports the hypothesis that neuroendocrine impairments in PCOS affect the coupling of kisspeptin with LH pulses and potentially worsen as the disease progresses, becoming unequivocally evident in oligomenorrheic PCOS patients. |
| Databáze: | OpenAIRE |
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