Cytotoxicity of anti-tumor herbal Marsdeniae tenacissimae extract on erythrocytes

Autor: Zhen Wang, Yu Zhang, Bingyu Chen, Cai-xia Li, Ke Hao, Meng-Hua Zhu, Kaiqiang Li, Wei Zhang, Jiang Shen, Xiang-Chai Guo, Ying Wang, Lu-Xi Jiang
Rok vydání: 2017
Předmět:
0301 basic medicine
Erythrocytes
medicine.medical_treatment
chemistry.chemical_element
Antineoplastic Agents
Apoptosis
Calcium
Pharmacology
Hemolysis
Article
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Neoplasms
medicine
Humans
Scattering
Radiation
General Pharmacology
Toxicology and Pharmaceutics
Fragmentation (cell biology)
Cytotoxicity
Cellular Senescence
Antitumor activity
chemistry.chemical_classification
Reactive oxygen species
Dose-Response Relationship
Drug
General Veterinary
Plant Extracts
Chemistry
Marsdenia
General Medicine
Flow Cytometry
medicine.disease
Glucose
030104 developmental biology
Biochemistry
Chemotherapy
Adjuvant
030220 oncology & carcinogenesis
High glucose
Reactive Oxygen Species
Adjuvant
Drugs
Chinese Herbal
Zdroj: Journal of Zhejiang University-SCIENCE B. 18:597-604
ISSN: 1862-1783
1673-1581
DOI: 10.1631/jzus.b1600228
Popis: Marsdeniae tenacissimae extract (MTE) has been used as an adjuvant medicine for cancer therapy for a long time. Although massive studies demonstrated its considerable anti-cancer effect, there is no research on its influence on erythrocytes, which are firstly interacted with MTE in the circulation. To investigate the influence of MTE on erythrocytes, we used a flow cytometer to detect the MTE-treated alternations of morphology, calcium concentration, and reactive oxygen species (ROS) level in erythrocytes. We used hemolysis under different osmotic solutions to evaluate the fragility of erythrocytes. Data showed that MTE treatment dose-dependently increased the ratio of erythrocyte fragmentation (P
Databáze: OpenAIRE
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