Effects of intravenous immunoglobulin therapy on behavior deficits and functions in sepsis model
| Autor: | Figen Esen, Nadir Arican, Günseli Orhun, Evren Şentürk, Canan Yilmaz, Salih Gümrü, Perihan Ergin Özcan, Nurcan Orhan, Mehmet Kaya, Feyza Aricioglu |
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| Přispěvatelé: | Ozcan, Perihan Ergin, Senturk, Evren, Orhun, Gunseli, Gumru, Salih, Arican, Nadir, Orhan, Nurcan, Yilmaz, Canan Ugur, Kaya, Mehmet, Aricioglu, Feyza, Esen, Figen, School of Medicine, Department of Physiology |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Elevated plus maze
medicine.medical_specialty STRESS medicine.drug_class Antibiotics INHIBITION Immunoglobulins REVERSES Critical Care and Intensive Care Medicine Gastroenterology Immunoglobulin G Open field PARAMETERS RATS Sepsis Intravenous Immunoglobulin Therapy Internal medicine medicine Medicine Physiology Forced swimming test Behavioral alteration biology business.industry BLOOD-BRAIN-BARRIER Research MEMORY Cecal ligation and puncture BREAKDOWN medicine.disease COGNITIVE IMPAIRMENT General and internal medicine Critical care medicine Plus maze test CECAL LIGATION Immunology biology.protein Antibody business Behavioural despair test |
| Zdroj: | Annals of Intensive Care |
| Popis: | Background: We aim to demonstrate behavioral alterations in a sepsis model using intravenous (IV) immunoglobulin G (IgG) and immunoglobulins enriched with IgA and IgM (IgGAM). Methods: We divided 48 Wistar albino rats into five groups: control group, sham-operated group (only antibiotic treatment), cecal ligation and puncture (CLP) group (CLP plus antibiotic treatment), IgG group (250 mg/kg IV IgG) and IgGAM group (250 mg/kg IV IgGAM). Intravenous immunoglobulins were given 5 min after the CLP procedure. Experimental animals put into three behavioral tasks 10, 30 and 60 days after the surgery; to evaluate the locomotor activity, an open field test was performed, elevated plus maze test was used to measure anxiety levels, and depressive state was assessed by forced swimming test. The effects of therapy which were acquired from the results of these tests were used to estimate the behavioral changes after CLP. Results: The mortality rate of 50% in the septic rats decreased to 30 and 20% with the administration of IgG and IgGAM, respectively. Significant changes on locomotor activity and depressive-like behavior were reported in the sepsis group; on the other hand, the treatment with immunoglobulins reduced the symptoms. Treatment with immunoglobulins attenuated the sepsis-related anxiogenic-like responses. Behavioral alterations returned to normal on day 60 in all groups. NA |
| Databáze: | OpenAIRE |
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