Ki67 immunostaining in primary breast cancer: pathological and clinical associations
| Autor: | Ian O. Ellis, R.W. Blamey, J.F.R. Robertson, Keith Griffiths, C.W. Elston, Robert Ian Nicholson, N. Bouzubar, K.J. Walker |
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| Jazyk: | angličtina |
| Rok vydání: | 1989 |
| Předmět: |
Adult
Cancer Research Pathology medicine.medical_specialty medicine.medical_treatment Mammary gland Breast Neoplasms Breast cancer Antigen medicine Humans Pathological biology Staining and Labeling business.industry Antibodies Monoclonal Middle Aged medicine.disease Prognosis medicine.anatomical_structure Oncology Monoclonal biology.protein Female Antibody Neoplasm Recurrence Local business Immunostaining Mastectomy Cell Division Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Ki67 immunostaining has been performed on 136 primary breast cancers and related to various clinical and pathological features of the disease. Staining was most frequently seen in poorly differentiated tumours showing high rates of mitotic activity, but was independent of tumour size, lymph-node status and ER expression. A high level of Ki67 immunostaining was often associated with early recurrence of breast cancer after mastectomy. These data are consistent with the concept of the Ki67 antibody detecting an antigen that is closely related to cell proliferation and thus provides a clinically useful marker for this important characteristic of the tumour. Images Figure 1 |
| Databáze: | OpenAIRE |
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