Comparison Between (311-312 nm) Narrow Band Ultraviolet-B Phototherapy and (308 nm) Monochromatic Excimer Light Phototherapy in Treatment of Vitiligo: A Histopathological Study
| Autor: | Dalia Gamal Aly, Noha S. Hanafy, Manal Mohamed Salah Eldin, Nevein Ahmed Sami |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Urology medicine.medical_treatment Labeling index Dermatology Vitiligo Excimer 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases medicine Dentistry (miscellaneous) Orthopedics and Sports Medicine skin and connective tissue diseases Light phototherapy integumentary system Excimer laser business.industry Ultraviolet b medicine.disease Narrow band Nephrology 030220 oncology & carcinogenesis Surgery Original Article Monochromatic color business |
| Zdroj: | Journal of lasers in medical sciences. 8(3) |
| ISSN: | 2008-9783 |
| Popis: | Introduction: Recently, the monochromatic excimer light (MEL) of 308 nm wavelength has shown some advantages in comparison to narrow band ultraviolet B (NB-UVB) for the treatment of vitiligo. To histopathologically compare the early effects of NB-UVB and 308-nm MEL phototherapy on vitiliginous patches using HE Identifier: PACTR201705002279419) Results: All lesions before treatment had labeling index (number of pigmented cells/non-pigmented cells) of 0.0 (0%). After treatment the LI for MEL was 4.2 ± 2.6, while for NB-UVB LI it was 0.3 ± 0.7. MEL showed higher statistical significance regarding increase of basal pigmented cells, and significant decrease in vacuolated keratinocytes and basal membrane thickness than NB-UVB. Conclusion: Although NB-UVB is considered as treatment of choice for vitiligo, MEL is acknowledged as an effective treatment modality for vitiliginous lesions that induces more repigmentation than NB-UVB, and more rapidly, as confirmed by our study. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|