A Cross-Linking Approach to Stabilizing Stimuli-Responsive Colloidal Crystals Engineered with DNA
| Autor: | Lee Seungkyu, Cindy Y. Zheng, Katherine E. Bujold, Chad A. Mirkin |
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| Rok vydání: | 2019 |
| Předmět: |
Stimuli responsive
Surface Properties Base pair 010402 general chemistry 01 natural sciences Biochemistry Catalysis chemistry.chemical_compound Colloid and Surface Chemistry Scattering Small Angle Colloids Particle Size Chemistry DNA General Chemistry Colloidal crystal Combinatorial chemistry 0104 chemical sciences Neutron Diffraction Cross-Linking Reagents Covalent bond Ethylnitrosourea Reagent Methoxsalen Gold Crystallization |
| Zdroj: | Journal of the American Chemical Society. 141:11827-11831 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/jacs.9b06106 |
| Popis: | Two DNA-cross-linking reagents, bis-chloroethylnitrosourea and 8-methoxypsoralen, are used to covalently cross-link interstrand base pairs in DNA bonds that, in part, define colloidal crystals engineered with DNA. The irreversible linkages formed increase the chemical and thermal stability of the crystals and do not significantly affect their long-range order, as evidenced by small-angle X-ray scattering data. The post-modified crystals are stable in environments that the pre-modified structures are not, including solvents that encompass a broad range of polarities from ethanol to hexanes, and in aqueous media at pH 0 and 14. Interestingly, the cross-linked DNA bonds within these crystals still retain their flexibility, which is reflected by a solvent-dependent reversible change in lattice parameter. Since these organic cross-linking reagents, in comparison with inorganic approaches (use of silver ions or SiO |
| Databáze: | OpenAIRE |
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