Severe global amnesia presenting as Wernicke–Korsakoff syndrome but resulting from atypical lesions
| Autor: | D.E. King, Peter R. Martin, Ronald C. Kessler, L. W. Welch, A. Nimmerrichter, R. Margolin, R. Hoehn |
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| Rok vydání: | 1996 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Pathology Mammillary Bodies Mammillary body Encephalopathy Amnesia Neuropsychological Tests Atrophy Alcohol Amnestic Disorder medicine Humans Wernicke Encephalopathy Memory disorder Applied Psychology Brain Mapping Wernicke–Korsakoff syndrome Cerebellar ataxia Brain Middle Aged medicine.disease Magnetic Resonance Imaging Surgery Psychiatry and Mental health Female medicine.symptom Energy Metabolism Psychology Tomography Emission-Computed |
| Zdroj: | Psychological Medicine. 26:421-425 |
| ISSN: | 1469-8978 0033-2917 |
| Popis: | SynopsisA female alcoholic presented with Wernicke's encephalopathy subsequent to administration of diazepam and glucose (without thiamine) for treatment of withdrawal seizures. Nystagmus and cerebellar ataxia quickly resolved when administered thiamine, although severe global amnesia consistent with Korsakoffs syndrome persisted. Magnetic resonance imaging (MRI) revealed infarction of the right temporal lobe with hippocampal atrophy, but no lesions of thalamus or atrophy of mammillary bodies. Positron emission tomography (PET) confirmed decreased cerebral metabolic rates for glucose (CMRglu) in the right temporal lobe corresponding to MRI findings, but also significant metabolic asymmetry of dorsal thalamus, i.e reduced CMRglu in left versus right. This patient is unique in that neuroradiological findings revealed intact mammillary bodies and suggest asymmetrical dysfunctions (structural right temporal and functional left diencephalic) to produce her profound amnesia. |
| Databáze: | OpenAIRE |
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