IL15 levels on day 7 after hematopoietic cell transplantation predict chronic GVHD
| Autor: | Yiping Liu, Andrew W. Lyon, Alejandra Ugarte-Torres, Tyler Williamson, Laura M. Pratt, Peter Podgorny, Andrew Daly, Faisal Khan, Jan Storek, M A Chaudhry, James A. Russell, D A Stewart, Andrew Grigg, Mette Hoegh-Petersen, David Ritchie |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Graft vs Host Disease Hematopoietic stem cell transplantation Gastroenterology Cohort Studies Young Adult immune system diseases hemic and lymphatic diseases Internal medicine medicine Humans IL-2 receptor Aged Interleukin-15 Transplantation Hematology Leukemia business.industry Hematopoietic Stem Cell Transplantation Middle Aged medicine.disease Fludarabine Immunology Chronic Disease Multivariate Analysis Biomarker (medicine) Female Complication business medicine.drug |
| Zdroj: | Bone marrow transplantation. 48(5) |
| ISSN: | 1476-5365 |
| Popis: | Chronic GVHD (cGVHD) is an important complication of allogeneic hematopoietic cell transplantation (HCT). As preemptive therapy might be efficacious if administered early post transplant, we set out to determine whether cGVHD can be predicted from the serum level of a biomarker on day 7 or 28. In a discovery cohort of 153 HCT recipients conditioned with BU, fludarabine and rabbit antithymocyte globulin (ATG), we determined serum levels of B-cell-activating factor, vascular endothelial growth factor, soluble TNF-α receptor 1, soluble IL2 receptor α, IL5, IL6, IL7, IL15, γ-glutamyl transpeptidase, cholinesterase, total protein, urea and ATG. Patients with low levels of IL15 ( |
| Databáze: | OpenAIRE |
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