Age-Specific Excess Mortality Patterns During the 1918-1920 Influenza Pandemic in Madrid, Spain
| Autor: | Laura Cilek, Diego Ramiro Fariñas, Gerardo Chowell |
|---|---|
| Přispěvatelé: | European Commission, Ministerio de Economía y Competitividad (España), Ramiro Fariñas, Diego, Chowell, Gerardo, Cilek, Laura Ann, Ramiro Fariñas, Diego [0000-0002-2766-307X], Chowell, Gerardo [0000-0003-2194-2251], Cilek, Laura Ann [0000-0002-0096-6337] |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Adolescent Epidemiology Epidemiology in History Mortality baseline Excess mortality Age-specific mortality patterns 03 medical and health sciences Young Adult 0302 clinical medicine Age Distribution Age groups Pandemic Influenza Human medicine Drosophila Proteins Humans 1918 pandemic 030212 general & internal medicine Young adult Child Aged Herald wave business.industry Mortality rate Outbreak Receptor Protein-Tyrosine Kinases Influenza pandemic History 20th Century Middle Aged Cadherins Influenza 3. Good health 030104 developmental biology Spain Child Preschool Female business Demography Influenza Pandemic 1918-1919 |
| Zdroj: | American Journal of Epidemiology Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1476-6256 |
| Popis: | Although much progress has been made to uncover age-specific mortality patterns of the 1918 influenza pandemic in populations around the world, more studies in different populations are needed to make sense of the heterogeneous death impact of this pandemic. We assessed the absolute and relative magnitudes of 3 pandemic waves in the city of Madrid, Spain, between 1918 and 1920, on the basis of age-specific all-cause and respiratory excess death rates. Excess death rates were estimated using a Serfling model with a parametric bootstrapping approach to calibrate baseline death levels with quantified uncertainty. Excess all-cause and pneumonia and influenza mortality rates were estimated for different pandemic waves and age groups. The youngest and oldest persons experienced the highest excess mortality rates, and young adults faced the highest standardized mortality risk. Waves differed in strength; the peak standardized mortality risk occurred during the herald wave in spring 1918, but the highest excess rates occurred during the fall and winter of 1918/1919. Little evidence was found to support a ¿W¿-shaped, age-specific excess mortality curve. Acquired immunity may have tempered a protracted fall wave, but recrudescent waves following the initial 2 outbreaks heightened the total pandemic mortality impact. |
| Databáze: | OpenAIRE |
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