Oral Recombinant Methioninase Overcomes Colorectal-cancer Liver Metastasis Resistance to the Combination of 5-Fluorouracil and Oxaliplatinum in a Patient-derived Orthotopic Xenograft Mouse Model
| Autor: | Qinghong Han, Kentaro Miyake, Yasunori Tome, Sang Nam Yoon, Thinzar M. Lwin, Fuminori Kanaya, Michael Bouvet, Bryan M. Clary, Robert M. Hoffman, Zhiying Zang, Yuki Katsuya, Hiromichi Oshiro, Tasuku Kiyuna, Jun Ho Park, Sahar Razmjooei, Takashi Higuchi, Kotaro Nishida, Yuying Tan, Shree Ram Singh, Norihiko Sugisawa |
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| Rok vydání: | 2019 |
| Předmět: |
Antimetabolites
Antineoplastic Cancer Research Combination therapy Colorectal cancer Oxaliplatinum Metastasis law.invention Mice 03 medical and health sciences 0302 clinical medicine Nude mouse law Antineoplastic Combined Chemotherapy Protocols Animals Humans Medicine biology business.industry Liver Neoplasms General Medicine medicine.disease biology.organism_classification Xenograft Model Antitumor Assays Oxaliplatin Carbon-Sulfur Lyases Disease Models Animal Oncology Fluorouracil 030220 oncology & carcinogenesis Cancer research Recombinant DNA Colorectal Neoplasms business medicine.drug |
| Zdroj: | Anticancer Research. 39:4667-4671 |
| ISSN: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.13648 |
| Popis: | BACKGROUND/AIM Liver metastasis in colorectal-cancer is a recalcitrant disease. To develop precision individualized therapy of this disease, we developed a patient-derived orthotopic xenograft (PDOX) model of colorectal-cancer liver metastasis. In the present report, we evaluated the efficacy of oral recombinant methioninase (o-rMETase) in combination with 5-fluorouracil (5-FU) and oxaliplatinum (OXA) on the colorectal-cancer liver metastasis PDOX mouse model. MATERIALS AND METHODS Colorectal-cancer liver metastasis PDOX models were randomized into three groups of seven mice. Group 1, untreated control with phosphate buffered saline (PBS); Group 2, treated with 5-FU + OXA; and Group 3, treated with 5-FU + OXA + o-rMETase. RESULTS The colorectal-cancer liver metastasis PDOX model was resistant to 5-FU + OXA (p=0.83 at day 15 of treatment, Group 2). In contrast, the colorectal-cancer liver metastasis PDOX model was arrested by o-rMETase combined with 5-FU + OXA (p |
| Databáze: | OpenAIRE |
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