Oestradiol measurement during fulvestrant treatment for breast cancer
| Autor: | Claire E Higham, Anne C Armstrong, Phillip J. Monaghan, Brian G. Keevil, Zena Salih, Sacha J Howell, Laura Owen |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Oncology
Adult Cancer Research medicine.medical_specialty Adolescent Population Context (language use) Breast Neoplasms Brief Communication 03 medical and health sciences Young Adult 0302 clinical medicine Breast cancer Tandem Mass Spectrometry Internal medicine medicine Humans Oestrogen receptor education Fulvestrant education.field_of_study medicine.diagnostic_test Estradiol business.industry Middle Aged medicine.disease Oestradiol measurement Clinical trial 030220 oncology & carcinogenesis Immunoassay Female Estrogen Receptor Antagonists business Hormonal therapies medicine.drug Chromatography Liquid |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Biochemical evaluation of menopausal status is used to inform treatment decisions, including clinical trial eligibility in women with oestrogen receptor positive breast cancer. However, fulvestrant may interfere with oestradiol immunoassays and confound accurate assessment in this context. We conducted a service evaluation of two immunoassays and an LC-MS/MS assay to determine the extent of the interference. Serum oestradiol levels were analysed by two immunoassays (Siemens Centaur XP and Abbott Architect) and liquid chromatography-tandem mass spectrometry (LC/MS/MS). Immunoassay gave higher serum oestradiol results than LC-MS/MS at low concentrations, with improved analytical sensitivity demonstrated by LC-MS/MS. Cross-reactivity of fulvestrant was observed for each immunoassay. We have shown that two commonly used immunoassays do not demonstrate the required sensitivity or specificity for the measurement of oestradiol in a breast cancer population. For patients receiving fulvestrant, spurious results may be generated that could impact treatment decisions. LC-MS/MS is recommended in this setting. |
| Databáze: | OpenAIRE |
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