Mast Cell Responses to Viruses and Pathogen Products
| Autor: | Liliana Portales-Cervantes, Jean S. Marshall, Edwin Leong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Chemokine medicine.medical_treatment Review Models Biological Catalysis Inorganic Chemistry lcsh:Chemistry 03 medical and health sciences 0302 clinical medicine Immune system Cancer immunotherapy Immunity Interferon medicine Animals Humans NK cell Mast Cells Physical and Theoretical Chemistry Molecular Biology lcsh:QH301-705.5 Spectroscopy Bacteria biology Effector Organic Chemistry chemokine General Medicine Immunotherapy interferon asthma Mast cell infection Computer Science Applications Culicidae 030104 developmental biology medicine.anatomical_structure oncolytic lcsh:Biology (General) lcsh:QD1-999 Viruses Immunology biology.protein immunotherapy mast cell 030215 immunology medicine.drug |
| Zdroj: | International Journal of Molecular Sciences, Vol 20, Iss 17, p 4241 (2019) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | Mast cells are well accepted as important sentinel cells for host defence against selected pathogens. Their location at mucosal surfaces and ability to mobilize multiple aspects of early immune responses makes them critical contributors to effective immunity in several experimental settings. However, the interactions of mast cells with viruses and pathogen products are complex and can have both detrimental and positive impacts. There is substantial evidence for mast cell mobilization and activation of effector cells and mobilization of dendritic cells following viral challenge. These cells are a major and under-appreciated local source of type I and III interferons following viral challenge. However, mast cells have also been implicated in inappropriate inflammatory responses, long term fibrosis, and vascular leakage associated with viral infections. Progress in combating infection and boosting effective immunity requires a better understanding of mast cell responses to viral infection and the pathogen products and receptors we can employ to modify such responses. In this review, we outline some of the key known responses of mast cells to viral infection and their major responses to pathogen products. We have placed an emphasis on data obtained from human mast cells and aim to provide a framework for considering the complex interactions between mast cells and pathogens with a view to exploiting this knowledge therapeutically. Long-lived resident mast cells and their responses to viruses and pathogen products provide excellent opportunities to modify local immune responses that remain to be fully exploited in cancer immunotherapy, vaccination, and treatment of infectious diseases. |
| Databáze: | OpenAIRE |
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