Extracellular Matrix Proteins and Transcription of Matrix-Associated Genes in Mesenchymal Stromal Cells during Modeling of the Effects of Microgravity

Autor:	A. Yu. Ratushnyy, I. V. Zhivodernikov, Ludmila Buravkova, D. K. Matveeva
Rok vydání:	2020
Předmět:	0301 basic medicine Protein subunit Tenascin Bone Marrow Cells General Biochemistry Genetics and Molecular Biology Bone and Bones Extracellular matrix 03 medical and health sciences 0302 clinical medicine Laminin Transcription (biology) Matrix Metalloproteinase 11 Osteogenesis Extracellular Cell Adhesion Humans Cell adhesion Weightlessness Simulation Tissue Inhibitor of Metalloproteinase-3 Extracellular Matrix Proteins Tissue Inhibitor of Metalloproteinase-1 biology Chemistry Weightlessness Mesenchymal stem cell Mesenchymal Stem Cells General Medicine Cell biology Extracellular Matrix 030104 developmental biology Adipose Tissue biology.protein Transcriptome Protein Processing Post-Translational 030217 neurology & neurosurgery
Zdroj:	Bulletin of experimental biology and medicine. 170(2)
ISSN:	1573-8221
Popis:	We studied the effects of simulated microgravity (10 days) on the production of extracellular matrix proteins and expression of extracellular matrix-associated genes in human mesenchymal stem cells. A decrease in collagen production, reduced expression of TIMP-1, TIMP-3, and MMP-11 genes, and enhanced expression of tenascin and laminin subunit were revealed. The results attest to activation of proteolytic processes in the matrix of mesenchymal stromal cells and weakening of cell adhesion to extracellular matrix under conditions of simulated microgravity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ef00e0b4d95d26d923c453bda26968 https://pubmed.ncbi.nlm.nih.gov/33263858 Zobrazit plný text záznamu Full text from SpringerLink