Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
| Autor: | Falk Hlubek, Ruth Knuechel, Thomas Kirchner, Leoni A. Kunz-Schughart, Simone Reu, Thomas Brabletz, Andreas Jung, Marc Porzner |
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| Rok vydání: | 2001 |
| Předmět: |
Genes
APC Beta-catenin Cell division Cellular differentiation Gene Expression Biology Gene expression Humans Neoplasm Invasiveness beta Catenin DNA Primers Multidisciplinary Base Sequence Cadherin Cell Differentiation Biological Sciences Cadherins Phenotype Cytoskeletal Proteins Tumor progression Catenin Immunology Trans-Activators Cancer research biology.protein Colorectal Neoplasms Cell Division |
| Zdroj: | Proceedings of the National Academy of Sciences. 98:10356-10361 |
| ISSN: | 1091-6490 0027-8424 |
| Popis: | Invasion and dissemination of well-differentiated carcinomas are often associated with loss of epithelial differentiation and gain of mesenchyme-like capabilities of the tumor cells at the invasive front. However, when comparing central areas of primary colorectal carcinomas and corresponding metastases, we again found the same differentiated epithelial growth patterns. These characteristic phenotypic changes were associated with distinct expression patterns of β-catenin, the main oncogenic protein in colorectal carcinomas, and E-cadherin. Nuclear β-catenin was found in dedifferentiated mesenchyme-like tumor cells at the invasive front, but strikingly, as in central areas of the primary tumors, was localized to the membrane and cytoplasm in polarized epithelial tumor cells in the metastases. This expression pattern was accompanied by changes in E-cadherin expression and proliferative activity. On the basis of these data, we postulate that an important driving force for progression of well-differentiated colorectal carcinomas is the specific environment, initiating two transient phenotypic transition processes by modulating intracellular β-catenin distribution in tumor cells. |
| Databáze: | OpenAIRE |
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