Experimental hypothyroidism induces cardiac arrhythmias and ranolazine reverts and prevents the phenotype
| Autor: | Diego Santos Souza, Leisiane Pereira Marques, Alexandre Dantas Costa, Jader Santos Cruz, Paula Rhana, Artur Santos-Miranda, Julliane Vasconcelos Joviano-Santos, Aimée Obolari Durço, Carla Maria Lins Vasconcelos, Danilo Roman-Campos |
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| Rok vydání: | 2022 |
| Předmět: |
Male
History Methimazole Polymers and Plastics Sodium Action Potentials Arrhythmias Cardiac General Medicine Industrial and Manufacturing Engineering General Biochemistry Genetics and Molecular Biology Mice Phenotype Hypothyroidism Ranolazine Caffeine Dobutamine Animals Myocytes Cardiac Business and International Management General Pharmacology Toxicology and Pharmaceutics |
| Zdroj: | Life Sciences. 308:120945 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/j.lfs.2022.120945 |
| Popis: | Hypothyroidism is associated with an increased risk of cardiovascular disease and enhanced susceptibility to arrhythmias. In our investigation, we evaluated the potential involvement of late sodium current (IMale Swiss mice were treated with methimazole (0.1 % w/vol, during 21 days) to induce experimental hypothyroidism before ECG, action potential (AP) and intracellular CaThe results revealed that hypothyroid animals presented ECG alterations (e.g. increased QTc) with the presence of spontaneous sustained ventricular tachycardia. These changes were associated with depolarized resting membrane potential in isolated cardiomyocytes and increased AP duration and dispersion at 90 % of the repolarization. Aberrant AP waveforms were related to increased CaWe concluded that animals with hypothyroidism have increased susceptibility to developing arrhythmias and ranolazine, a clinically used blocker of I |
| Databáze: | OpenAIRE |
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