Topical photodynamic therapy significantly reduces epidermal Langerhans cells during clinical treatment of basal cell carcinoma
| Autor: | A. D. Tosca, Mark D. Farrar, S. Andrew, Lindsay Cotterell, Rachel E.B. Watson, G. Evangelou, Lesley E. Rhodes |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Pathology medicine.medical_specialty Skin Neoplasms medicine.medical_treatment Photodynamic therapy Dermatology Administration Cutaneous law.invention Immune system Randomized controlled trial law medicine Carcinoma Humans Basal cell carcinoma Aged Photosensitizing Agents business.industry Immunosuppression Aminolevulinic Acid Middle Aged medicine.disease eye diseases Neutrophil Infiltration Photochemotherapy Carcinoma Basal Cell Langerhans Cells Cancer research Immunohistochemistry Female business Infiltration (medical) |
| Zdroj: | British Journal of Dermatology. 166:1112-1115 |
| ISSN: | 1365-2133 0007-0963 |
| DOI: | 10.1111/j.1365-2133.2012.10823.x |
| Popis: | Background Topical photodynamic therapy (PDT) is a widely applied treatment for basal cell carcinoma (BCC). PDT-induced immunosuppression leading to reduced antitumour immune responses may be a factor in treatment failure. Objectives To examine the impact of topical PDT on leucocyte trafficking following clinical treatment of BCC. Methods Superficial BCCs in eight white caucasian patients were treated with methyl aminolaevulinate (MAL)-PDT. Biopsies for immunohistochemical assessment were taken from BCCs pre-PDT, 1 h and 24 h post-PDT and from untreated healthy skin. Results Treatment of BCC with MAL-PDT produced a rapid neutrophil infiltration, commencing by 1 h and significantly increased at 24 h post-PDT (P |
| Databáze: | OpenAIRE |
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