NuMoM2b Sleep-Disordered Breathing study: objectives and methods
Autor: | Chia Ling Nhan-Chang, Daniel Mobley, Hyagriv N. Simhan, Samuel Parry, Deborah A. Wing, William A. Grobman, Susan Redline, David M. Haas, Judith H. Chung, Brian M. Mercer, Frank Schubert, Uma M. Reddy, Corette B. Parker, Matthew A. Koch, Phyllis C. Zee, Robert M. Silver, George R. Saade, Robert C. Basner, Francesca L. Facco, Judette Louis, Grace W. Pien |
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Rok vydání: | 2015 |
Předmět: |
Gestational hypertension
Pediatrics Polysomnography Reproductive health and childbirth Cardiovascular Low Birth Weight and Health of the Newborn Clinical Protocols Risk Factors Pregnancy Infant Mortality Medicine and Health Sciences Prospective Studies Prospective cohort study Lung Pediatric medicine.diagnostic_test Pregnancy Outcome home sleep test Obstetrics and Gynecology Apnea Gestational diabetes Research Design Cohort Female medicine.symptom Sleep Research Hypopnea Adult medicine.medical_specialty Adolescent Article methods Paediatrics and Reproductive Medicine Young Adult Sleep Apnea Syndromes Double-Blind Method Clinical Research Preterm Behavioral and Social Science medicine Humans Conditions Affecting the Embryonic and Fetal Periods sleep Obstetrics & Reproductive Medicine business.industry Contraception/Reproduction sleep-disordered breathing Neurosciences Perinatal Period - Conditions Originating in Perinatal Period medicine.disease Pregnancy Complications Good Health and Well Being Physical therapy business |
Zdroj: | American journal of obstetrics and gynecology, vol 212, iss 4 Facco, Francesca L; Parker, Corette B; Reddy, Uma M; Silver, Robert M; Louis, Judette M; Basner, Robert C; et al.(2015). NuMoM2b Sleep-Disordered Breathing study: objectives and methods. American Journal of Obstetrics and Gynecology, 212(4), 542.e1-542.e127. doi: 10.1016/j.ajog.2015.01.021. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/33t6237x |
DOI: | 10.1016/j.ajog.2015.01.021. |
Popis: | ObjectiveThe objective of the Sleep Disordered Breathing substudy of the Nulliparous Pregnancy Outcomes Study Monitoring Mothers-to-be (nuMoM2b) is to determine whether sleep disordered breathing during pregnancy is a risk factor for adverse pregnancy outcomes.Study designNuMoM2b is a prospective cohort study of 10,037 nulliparous women with singleton gestations that was conducted across 8 sites with a central Data Coordinating and Analysis Center. The Sleep Disordered Breathing substudy recruited 3702 women from the cohort to undergo objective, overnight in-home assessments of sleep disordered breathing. A standardized level 3 home sleep test was performed between 6(0)-15(0) weeks' gestation (visit 1) and again between 22(0)-31(0) weeks' gestation (visit 3). Scoring of tests was conducted by a central Sleep Reading Center. Participants and their health care providers were notified if test results met "urgent referral" criteria that were based on threshold levels of apnea hypopnea indices, oxygen saturation levels, or electrocardiogram abnormalities but were not notified of test results otherwise. The primary pregnancy outcomes to be analyzed in relation to maternal sleep disordered breathing arepreeclampsia, gestational hypertension, gestational diabetes mellitus, fetal growth restriction, and preterm birth.ResultsObjective data were obtained at visit 1 on 3261 women, which was 88.1% of the studies that were attempted and at visit 3 on2511 women, which was 87.6% of the studies that were attempted. Basic characteristics of the substudy cohort are reported inthis methods article.ConclusionThe substudy was designed to address important questions regarding the relationship of sleep-disordered breathing onthe risk of preeclampsia and other outcomes of relevance to maternal and child health. |
Databáze: | OpenAIRE |
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