NuMoM2b Sleep-Disordered Breathing study: objectives and methods

Autor: Chia Ling Nhan-Chang, Daniel Mobley, Hyagriv N. Simhan, Samuel Parry, Deborah A. Wing, William A. Grobman, Susan Redline, David M. Haas, Judith H. Chung, Brian M. Mercer, Frank Schubert, Uma M. Reddy, Corette B. Parker, Matthew A. Koch, Phyllis C. Zee, Robert M. Silver, George R. Saade, Robert C. Basner, Francesca L. Facco, Judette Louis, Grace W. Pien
Rok vydání: 2015
Předmět:
Gestational hypertension
Pediatrics
Polysomnography
Reproductive health and childbirth
Cardiovascular
Low Birth Weight and Health of the Newborn
Clinical Protocols
Risk Factors
Pregnancy
Infant Mortality
Medicine and Health Sciences
Prospective Studies
Prospective cohort study
Lung
Pediatric
medicine.diagnostic_test
Pregnancy Outcome
home sleep test
Obstetrics and Gynecology
Apnea
Gestational diabetes
Research Design
Cohort
Female
medicine.symptom
Sleep Research
Hypopnea
Adult
medicine.medical_specialty
Adolescent
Article
methods
Paediatrics and Reproductive Medicine
Young Adult
Sleep Apnea Syndromes
Double-Blind Method
Clinical Research
Preterm
Behavioral and Social Science
medicine
Humans
Conditions Affecting the Embryonic and Fetal Periods
sleep
Obstetrics & Reproductive Medicine
business.industry
Contraception/Reproduction
sleep-disordered breathing
Neurosciences
Perinatal Period - Conditions Originating in Perinatal Period
medicine.disease
Pregnancy Complications
Good Health and Well Being
Physical therapy
business
Zdroj: American journal of obstetrics and gynecology, vol 212, iss 4
Facco, Francesca L; Parker, Corette B; Reddy, Uma M; Silver, Robert M; Louis, Judette M; Basner, Robert C; et al.(2015). NuMoM2b Sleep-Disordered Breathing study: objectives and methods. American Journal of Obstetrics and Gynecology, 212(4), 542.e1-542.e127. doi: 10.1016/j.ajog.2015.01.021. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/33t6237x
DOI: 10.1016/j.ajog.2015.01.021.
Popis: ObjectiveThe objective of the Sleep Disordered Breathing substudy of the Nulliparous Pregnancy Outcomes Study Monitoring Mothers-to-be (nuMoM2b) is to determine whether sleep disordered breathing during pregnancy is a risk factor for adverse pregnancy outcomes.Study designNuMoM2b is a prospective cohort study of 10,037 nulliparous women with singleton gestations that was conducted across 8 sites with a central Data Coordinating and Analysis Center. The Sleep Disordered Breathing substudy recruited 3702 women from the cohort to undergo objective, overnight in-home assessments of sleep disordered breathing. A standardized level 3 home sleep test was performed between 6(0)-15(0) weeks' gestation (visit 1) and again between 22(0)-31(0) weeks' gestation (visit 3). Scoring of tests was conducted by a central Sleep Reading Center. Participants and their health care providers were notified if test results met "urgent referral" criteria that were based on threshold levels of apnea hypopnea indices, oxygen saturation levels, or electrocardiogram abnormalities but were not notified of test results otherwise. The primary pregnancy outcomes to be analyzed in relation to maternal sleep disordered breathing arepreeclampsia, gestational hypertension, gestational diabetes mellitus, fetal growth restriction, and preterm birth.ResultsObjective data were obtained at visit 1 on 3261 women, which was 88.1% of the studies that were attempted and at visit 3 on2511 women, which was 87.6% of the studies that were attempted. Basic characteristics of the substudy cohort are reported inthis methods article.ConclusionThe substudy was designed to address important questions regarding the relationship of sleep-disordered breathing onthe risk of preeclampsia and other outcomes of relevance to maternal and child health.
Databáze: OpenAIRE