Application of partially aromatic ortho-quionone-methides for the synthesis of novel naphthoxazines with improved antibacterial activity

Autor:	Dóra Hegedűs, Nikoletta Szemerédi, Gabriella Spengler, István Szatmári
Rok vydání:	2022
Předmět:	Methicillin-Resistant Staphylococcus aureus Pharmacology Cycloaddition Reaction Organic Chemistry Drug Discovery Imines General Medicine Amino Acids Anti-Bacterial Agents
Zdroj:	European Journal of Medicinal Chemistry. 237:114391
ISSN:	0223-5234
DOI:	10.1016/j.ejmech.2022.114391
Popis:	Starting from naphthols and morpholine and using ethyl glyoxylate as the aldehyde component in the modified Mannich reaction, new aminonaphthol derivatives substituted with 2- and 1-naphthol were synthesised. The stabilization of precursor bifunctional compounds via partially aromatic ortho-quinone methide intermediate was tested with different cyclic imines in [4 + 2] cycloaddition. Based on
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e50976665bfa8b58c1778a182a8083 https://doi.org/10.1016/j.ejmech.2022.114391 Zobrazit plný text záznamu Full Text from ScienceDirect