Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man
| Autor: | John L. Ivy, Hannele Yki-Järvinen, Carol L Culter, Andrew A. Young, Timothy W. Secomb, Joanna K Zawadzki, L. Christin, William G H Abbott, Stephen Lillioja, C Bogardus |
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| Rok vydání: | 1987 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Adipose tissue Biology White People Insulin resistance Internal medicine medicine Humans Insulin Myocyte Obesity Fiber Pancreatic hormone Muscles Skeletal muscle Fasting General Medicine medicine.disease Capillaries medicine.anatomical_structure Endocrinology Adipose Tissue Indians North American Insulin Resistance Metabolic syndrome Research Article |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0021-9738 |
| DOI: | 10.1172/jci113088 |
| Popis: | We have compared the capillary density and muscle fiber type of musculus vastus lateralis with in vivo insulin action determined by the euglycemic clamp (M value) in 23 Caucasians and 41 Pima Indian nondiabetic men. M value was significantly correlated with capillary density (r = 0.63; P less than or equal to 0.0001), percent type I fibers (r = 0.29; P less than 0.02), and percent type 2B fibers (r = -0.38; P less than 0.003). Fasting plasma glucose and insulin concentrations were significantly negatively correlated with capillary density (r = -0.46, P less than or equal to 0.0001; r = -0.47, P less than or equal to 0.0001, respectively). Waist circumference/thigh circumference ratio was correlated with percent type 1 fibers (r = -0.39; P less than 0.002). These results suggest that diffusion distance from capillary to muscle cells or some associated biochemical change, and fiber type, could play a role in determining in vivo insulin action. The association of muscle fiber type with body fat distribution may indicate that central obesity is only one aspect of a more generalized metabolic syndrome. The data may provide at least a partial explanation for the insulin resistance associated with obesity and for the altered kinetics of insulin action in the obese. |
| Databáze: | OpenAIRE |
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