Inputs to the midbrain dopaminergic complex in the rat, with emphasis on extended amygdala-recipient sectors
| Autor: | Kenneth P. Parsely, Stefanie Geisler, Zachary M. Schwartz, R. W. Veh, Comeron W. Ghobadi, Anita Y. Cheng, Tristan J. Lee, Daniel S. Zahm, Clemens Gruber |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Brain Mapping Basal forebrain Pars compacta Dopamine General Neuroscience Striatum Biology Amygdala Article Rats Rats Sprague-Dawley Ventral tegmental area Midbrain Anterograde tracing medicine.anatomical_structure nervous system Extended amygdala Mesencephalon Neural Pathways medicine Animals Brainstem Neuroscience |
| Zdroj: | The Journal of Comparative Neurology. 519:3159-3188 |
| ISSN: | 0021-9967 |
| Popis: | The midbrain dopaminergic neuronal groups A8, A9, A10 and A10dc occupy, respectively, the retrorubral field (RRF), substantia nigra compacta (SNc), ventral tegmental area (VTA) and ventrolateral periaqueductal gray (PAGvl). Collectively, these structures give rise to a mixed dopaminergic and non-dopaminergic projection system that essentially permits adaptive behavior. Yet, knowledge is incomplete regarding how the afferents of these structures are organized. While the VTA is known to get numerous afferents from cortex, basal forebrain and brainstem and the SNc is widely perceived as receiving inputs mainly from the striatum, the afferents of the RRF and PAGvl have yet to be addressed comprehensively. This study was done to provide an account of those connections and seek a better understanding of how afferents might contribute to the functional interrelatedness of the VTA, SNc, RRF and PAGvl. Ventral midbrain structures received injections of retrograde tracer and resulting retrogradely labeled structures were targeted with injections of anterogradely transported Phaseolus vulgaris-leucoagglutinin. While all injections of retrograde tracer into the VTA, SNc, RRF or PAGvl produced labeling in many of a long list of structures extending from the cortex to caudal brainstem, pronounced labeling of structures comprising the central division of the extended amygdala occurred following injections that involved the RRF and PAGvl. The anterograde tracing supported this finding and, interestingly, the combination of retrograde and anterograde labeling data also confirmed reports from other groups indicating that the SNc receives robust input from many of the same structures that innervate the VTA, RRF and PAGvl. |
| Databáze: | OpenAIRE |
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