Exploring the Contribution of Myelin Content in Normal Appearing White Matter to Cognitive Outcomes in Cerebral Small Vessel Disease
| Autor: | Lisanne F. ten Brinke, Ging-Yuek R Hsiung, Youngjin Yoo, Alex L. MacKay, Teresa Liu-Ambrose, Elizabeth Dao, Rachel A. Crockett, Stephanie Doherty, Roger Tam, Cindy K. Barha, Walid Al Keridy, Cornelia Laule |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Trail Making Test Neuropsychological Tests Audiology 030218 nuclear medicine & medical imaging White matter 03 medical and health sciences Myelin Cognition 0302 clinical medicine Reaction Time Memory span medicine Humans Cognitive Dysfunction Myelin Sheath Aged Aged 80 and over Memory Disorders Working memory business.industry General Neuroscience Cognitive flexibility General Medicine Middle Aged Mental Status and Dementia Tests Executive functions Magnetic Resonance Imaging White Matter Hyperintensity Psychiatry and Mental health Clinical Psychology Memory Short-Term medicine.anatomical_structure Cerebral Small Vessel Diseases Stroop Test Female Geriatrics and Gerontology business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's Disease. 80:91-101 |
| ISSN: | 1875-8908 1387-2877 |
| Popis: | Background: Myelin damage is a salient feature in cerebral small vessel disease (cSVD). Of note, myelin damage extends into the normal appearing white matter (NAWM). Currently, the specific role of myelin content in cognition is poorly understood. Objective: The objective of this exploratory study was to investigate the association between NAWM myelin and cognitive function in older adults with cSVD. Methods: This exploratory study included 55 participants with cSVD. NAWM myelin was measured using myelin water imaging and was quantified as myelin water fraction (MWF). Assessment of cognitive function included processing speed (Trail Making Test Part A), set shifting (Trail Making Test Part B minus A), working memory (Verbal Digit Span Backwards Test), and inhibition (Stroop Test). Multiple linear regression analyses assessed the contribution of NAWM MWF on cognitive outcomes controlling for age, education, and total white matter hyperintensity volume. The overall alpha was set at ≤0.05. Results: After accounting for age, education, and total white matter hyperintensity volume, lower NAWM MWF was significantly associated with slower processing speed (β = –0.29, p = 0.037) and poorer working memory (β= 0.30, p = 0.048). NAWM MWF was not significantly associated with set shifting or inhibitory control (p > 0.132). Conclusion: Myelin loss in NAWM may play a role in the evolution of impaired processing speed and working memory in people with cSVD. Future studies, with a longitudinal design and larger sample sizes, are needed to fully elucidate the role of myelin as a potential biomarker for cognitive function. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|