[Programa de detección del alelo APOE-E4 en adultos mayores mexicanos con deterioro cognitivo]
Autor: | Janett Jiménez-Genchi, Nuria Lanzagorta, Humberto Nicolini, Rafael Guzmán, Andrés Roche, José Jaime Martínez-Magaña, Dione Aguilar-Méndez, Alma Delia Genis-Mendoza, Alexis Bojorge, Angélica Martínez-Hernández, Mariana Chávez, Lorena Orozco, Carolina Bojórquez, Thalía Fernández, Carlos Castañeda, José Alberto Téllez-Martínez, Leonor Zapata, Susana A. Castro-Chavira, Ileana Rebolledo |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Gynecology medicine.medical_specialty business.industry Apolipoprotein E4 General Medicine Principal factor Middle Aged Mexican population 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Risk Factors medicine Humans Cognitive Dysfunction Genetic Predisposition to Disease Genetic risk factor Genetic risk business Cognitive impairment Cognition Disorders Mexico 030217 neurology & neurosurgery Alleles |
Zdroj: | Gaceta medica de Mexico. 154(5) |
ISSN: | 0016-3813 |
Popis: | espanolIntroduccion: En Mexico, la prevalencia de los trastornos neurocognitivos (TNC) han aumentado a la par del incremento en la esperanza de vida. El alelo E4 del gen que codifica la apolipoproteina E (APOE) es el principal factor de riesgo genetico para deterioro neurocognitivo. Objetivo: Reproducir la asociacion en poblacion mexicana entre APOE-E4 y el deterioro neurocognitivo, asi como implementar un programa de deteccion de riesgo genetico con el alelo APOE-E4. Metodo: Se estructuro un programa de deteccion de riesgo basado en APO-EA en diferentes centros de reclutamiento en la zona centro de la Republica Mexicana, con tres etapas: reclutamiento y seleccion de los candidatos para la deteccion del alelo de riesgo, analisis del riesgo genetico y entrega del resultado. Resultados: El analisis de asociacion genetica para replicar la asociacion con trastornos neurocognitivos mediante modelos logisticos multivariados mostro que el alelo E4 de APOE incremento aproximadamente 6 % el riesgo en poblacion mexicana (RM = 5.83, p = 0.0025). Se entregaron 367 resultados de riesgo genetico. Conclusiones: El presente programa es el primero en Mexico implementado para dar a conocer un factor de riesgo genetico para trastornos neurocognitivos en varios centros del pais. EnglishIntroduction: In Mexico, the prevalence of neurocognitive disorders (NCDs) has increased in parallel with the increase in life expectancy. The E4 allele of the gene that encodes apolipoprotein E (APOE) is the main genetic risk factor for cognitive impairment. Objective: To replicate the association of APOE-E4 allele with neurocognitive impairment in a Mexican population, as well as to implement a genetic risk-detection program with the APOE-E4 allele. Method: A program was structured for the detection of APOE-E4 allele risk in different recruiting centers from the central zone of the Mexican Republic, with three stages: recruitment and selection of candidates for the detection of the risk-allele, genetic risk analysis and delivery of results. Results: In the genetic-association study to replicate the association with neurocognitive disorders by means of multivariate logistic models, the APOE-E4 allele increased the risk for cognitive impairment in the Mexican populations by approximately 6 % (OR: 5.83, p = 0.0025). In addition, 367 genetic risk results were delivered. Conclusions: The present program is the first one to be implemented in Mexico with the purpose to inform on a genetic risk factor for neurocognitive disorders in several centers of the country. |
Databáze: | OpenAIRE |
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