Characterisation of T cell phenotypes, cytokines and transcription factors in the skin of dogs with cutaneous adverse food reactions
| Autor: | Veenhof, E.Z., Schlotter, Y.M., Vernooij, Hans, Rutten, V.P., Willemse, T., Advances in Veterinary Medicine, Risk Assessment of Toxic and Immunomodulatory Agents, LS Theoretische Epidemiologie, Dep Infectieziekten Immunologie, Geneeskunde van gezelschapsdieren |
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| Rok vydání: | 2009 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male medicine.medical_specialty medicine.medical_treatment T cell T-Lymphocytes Biology CD8-Positive T-Lymphocytes Dermatitis Atopic Immunophenotyping Dogs Elimination diet Internal medicine Gene expression medicine Animals Dog Diseases Skin General Veterinary Reverse Transcriptase Polymerase Chain Reaction FOXP3 Atopic dermatitis medicine.disease Immunohistochemistry Cytokine medicine.anatomical_structure Endocrinology Immunology Cytokines Animal Science and Zoology Female Transcription Factor Gene CD8 Food Hypersensitivity |
| Zdroj: | Veterinary Journal, 187(3), 320. Bailliere Tindall Ltd |
| ISSN: | 1532-2971 1090-0233 |
| Popis: | The immunopathogenesis of cutaneous adverse food reactions (CAFRs) in dogs is unknown. Since the clinical manifestations in the skin are like those found in canine atopic dermatitis (AD), this study investigated the similarity in T cell phenotypes and gene expression of cytokines and transcription factors in CAFRs. In addition, the influence of an elimination diet on these parameters was tested. In the skin of canine CAFRs, a predominant presence of CD8+ T cells and increased expression of the IL-4, IL-13, Foxp3 and SOCS-3 genes were observed. IFN-γ gene expression was increased in lesional compared to non-lesional skin. The predominance of CD8+ T cells indicates that the immunopathogenesis of CAFRs is different from that of canine AD. The elimination diet relieved clinical signs, but did not influence T cell phenotypes or expression of the cytokine and transcription factor genes in the skin of dogs with CAFRs, indicating a continuously pre-activated immune status in dogs sensitised to food constituents. |
| Databáze: | OpenAIRE |
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