Genome-wide association study for radiographic vertebral fractures: A potential role for the 16q24 BMD locus

Autor: Ching-Ti Liu, Paul Lips, Fernando Rivadeneira, Nerea Alonso, Marjolein van der Klift, Stephen Kaptoge, Stuart H. Ralston, Karol Estrada, Liesbeth Vandenput, Claus Christiansen, David M. Evans, Ling Oei, Ghi Su Kim, Joshua R. Lewis, Dan Mellström, Unnur Styrkarsdottir, M. Carola Zillikens, David Karasik, Natasja M. van Schoor, Carolina Medina-Gomez, Huibert A. P. Pols, Josefina Martínez, Evangelia E. Ntzani, José A. Riancho, Lizbeth Herrera, Kun Zhu, Barbara Obermayer-Pietsch, Anna Daroszewska, Joyce B. J. van Meurs, John P. A. Ioannidis, Eugene V. McCloskey, Edwin H.G. Oei, José L. Hernández, Lisette Stolk, Bente L. Langdahl, Evangelos Evangelou, L. Adrienne Cupples, L. B. Husted, Östen Ljunggren, Richard L. Prince, Albert Hofman, Douglas P. Kiel, Magnus Karlsson, Martha C. Castaño-Betancourt, Claes Ohlsson, Jonathan Reeve, Seung Hun Lee, J. Brent Richards, Carmen Valero, Matthew A. Brown, Yi-Hsiang Hsu, André G. Uitterlinden, Emma L. Duncan, Jung-Min Koh
Přispěvatelé: Epidemiology and Data Science, Internal medicine, EMGO - Musculoskeletal health, EMGO+ - Musculoskeletal Health, Universidad de Cantabria, Internal Medicine, Radiology & Nuclear Medicine, Hematology, Epidemiology, International Institute of Social Studies
Rok vydání: 2014
Předmět:
Zdroj: Bone, 59, 20-27. Elsevier Inc.
Oei, L, Estrada, K, Duncan, E L, Christiansen, C, Liu, C-T, Langdahl, B L, Obermayer-Pietsch, B, Riancho, J A, Prince, R L, van Schoor, N M, McCloskey, E, Hsu, Y-H, Evangelou, E, Ntzani, E, Evans, D M, Alonso, N, Husted, L B, Valero, C, Hernandez, J L, Lewis, J R, Kaptoge, S K, Zhu, K, Cupples, L A, Medina-Gómez, C, Vandenput, L, Kim, G S, Hun Lee, S, Castaño-Betancourt, M C, Oei, E H G, Martinez, J, Daroszewska, A, van der Klift, M, Mellström, D, Herrera, L, Karlsson, M K, Hofman, A, Ljunggren, Ö, Pols, H A P, Stolk, L, van Meurs, J B J, Ioannidis, J P A, Zillikens, M C, Lips, P, Karasik, D, Uitterlinden, A G, Styrkarsdottir, U, Brown, M A, Koh, J-M, Richards, J B, Reeve, J, Ohlsson, C, Ralston, S H, Kiel, D P & Rivadeneira, F 2014, ' Genome-wide association study for radiographic vertebral fractures : a potential role for the 16q24 BMD locus ', Bone, vol. 59, pp. 20-7 . https://doi.org/10.1016/j.bone.2013.10.015
Oei, L, Estrada, K, Duncan, E L, Christiansen, C, Liu, C T, Langdahl, B L, Obermayer-Pietsch, B, Riancho, J A, Prince, R L, van Schoor, N M, McCloskey, E, Hsu, Y H, Evangelou, E, Ntzani, E, Evans, D M, Alonso, N, Husted, L B, Valero, C, Hernandez, J L, Lewis, J R, Kaptoge, S K, Zhu, K, Cupples, L A, Medina-Gomez, C, Vandenput, L, Kim, G S, Lee, S H, Castano-Betancourt, M C, Oei, E H G, Martinez, J, Daroszewska, A, van der Klift, M, Mellstrom, D, Herrera, L, Karlsson, M K, Hofman, A, Ljunggren, O, Pols, H A P, Stolk, L, van Meurs, J B J, Ioannidis, J P A, Zillikens, M C, Lips, P T A M, Karasik, D, Uitterlinden, A G, Styrkarsdottir, U, Brown, M A, Koh, J M, Richards, J B, Reeve, J, Ohlsson, C, Ralston, S H, Kiel, D P & Rivadeneira, F 2014, ' Genome-wide association study for radiographic vertebral fractures: A potential role for the 16q24 BMD locus ', Bone, vol. 59, pp. 20-27 . https://doi.org/10.1016/j.bone.2013.10.015
Bone. 2014 Feb;59:20-7
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
ISSN: 1164-5938
8756-3282
DOI: 10.1016/j.bone.2013.10.015
Popis: Vertebral fracture risk is a heritable complex trait. The aim of this study was to identify genetic susceptibility factors for osteoporotic vertebral fracture applying a genome-wide association study (GWAS) approach. The GWAS discovery was based on the Rotterdam Study, a population-based study of elderly Dutch individuals aged >55 years; and comprising 329 cases and 2666 controls with radiographic scoring (McCloskey-Kanis) and genetic data. Replication of one top-associated SNP was pursued by de-novo genotyping of 15 independent studies across Europe, the United States, and Australia and one Asian study. Radiographic vertebral fracture assessment was performed using McCloskey-Kanis or Genant semi-quantitative definitions. SNPs were analyzed in relation to vertebral fracture using logistic regression models corrected for age and sex. Fixed effects inverse variance and Han-Eskin alternative random effects meta-analyses were applied. Genome-wide significance was set at p1.25) may still be consistent with an effect size
Databáze: OpenAIRE
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