Important gene-gene interaction of TNF-α and VDR on osteoporosis in community-dwelling elders
| Autor: | Chiu-Shong Liu, Chuan Wei Yang, Chih Hsueh Lin, Li Na Liao, Fang Yang Wu, Chia Ing Li, Tsai-Chung Li, Cheng-Chieh Lin, Wen-Yuan Lin |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Heredity Bone density Physiology Osteoporosis Organic chemistry Pathology and Laboratory Medicine Calcitriol receptor 0302 clinical medicine Elderly Polymorphism (computer science) Bone Density Immune Physiology Genotype Medicine and Health Sciences Public and Occupational Health Vitamin D Connective Tissue Diseases Immune Response Aged 80 and over Innate Immune System Multidisciplinary Vitamins Physical sciences Chemistry Genetic Mapping medicine.anatomical_structure Connective Tissue Area Under Curve Medicine Cytokines Female Independent Living Anatomy Research Article medicine.medical_specialty Science Immunology Variant Genotypes Polymorphism Single Nucleotide 03 medical and health sciences Chemical compounds Signs and Symptoms Gene interaction Rheumatology Diagnostic Medicine Internal medicine Organic compounds medicine Genetics Humans Bone Femoral neck Aged Inflammation business.industry Tumor Necrosis Factor-alpha Genetic Variation Biology and Life Sciences Epistasis Genetic Odds ratio Physical Activity Molecular Development medicine.disease 030104 developmental biology Endocrinology Biological Tissue ROC Curve Age Groups Immune System People and Places Receptors Calcitriol Population Groupings business 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | PLoS ONE PLoS ONE, Vol 14, Iss 12, p e0226973 (2019) |
| ISSN: | 1932-6203 |
| Popis: | Gene effects on osteoporosis have been studied separately and may have been masked by gene-gene and gene-environment interactions. We evaluated gene-gene and gene-physical activity interactions of the variants of tumor necrosis factor-α (TNF-α) and vitamin D receptor (VDR) genes on osteoporosis. A total of 472 elders were included. Seven variants (TNF-α: rs1799964, rs1800629, rs3093662; VDR: rs7975232, rs1544410, rs2239185, rs3782905) were genotyped. Bone mineral densities of the lumbar spine, femoral neck, and total hip were measured by dual-energy X-ray absorptiometry. Predictive models' ability to discriminate osteoporosis status was evaluated by areas under the receiver operating characteristics (AUROC) curve. After multivariable adjustment, significant interactions of TNF-α rs1800629 and VDR rs3782905 were observed on overall and lumbar spine osteoporosis. In elderly women, we found that those carrying the CG/CC genotype of VDR rs3782905 were significantly associated with increased odds of overall osteoporosis compared with those carrying the GG genotype of VDR rs3782905 among those carrying TNF-α rs1800629 GG genotype. The adjusted odds ratios (ORs) for VDR rs3782905 CG/CC genotype in elderly women carrying TNF-α rs1800629 AG/AA and GG genotypes were 0.1 (0.01, 0.98) and 3.54 (1.51, 8.30), respectively. We observed significant differences in AUROCs between the model with traditional covariates plus variants and their interaction term and the model with traditional covariates only (AUROCs: 0.77 and 0.81; p = 0.028). Although the sample size of this study may have been relatively small, our results suggest that the interaction of the CG/CC genotype of VDR rs3782905 with TNF-α rs1800629 GG genotype was associated with increased odds of overall and lumbar spine osteoporosis in elderly women. |
| Databáze: | OpenAIRE |
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