Thyrotropin receptor autoantibodies and early miscarriages in patients with Hashimoto thyroiditis: a case–control study

Autor:	Dimitrios Vavilis, Dimitrios G. Goulis, Basil C. Tarlatzis, Marios Fragkos, Konstantina Tsolakidou, Ilias Hilidis, Konstantinos A Toulis, Antonios Gerofotis, Stergios A. Polyzos, Michail Daniilidis, Helen Bili, Marina Kita, Ioannis Papadimas
Rok vydání:	2013
Předmět:	Adult endocrine system medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Gestational Age Hashimoto Disease Gastroenterology Thyrotropin receptor Miscarriage Endocrinology Pregnancy Risk Factors Seroepidemiologic Studies Internal medicine medicine Humans Autoantibodies business.industry Pregnancy Outcome Autoantibody Case-control study Obstetrics and Gynecology Receptors Thyrotropin Middle Aged medicine.disease Anti-thyroid autoantibodies Abortion Spontaneous Exact test Case-Control Studies Immunology Etiology Female business hormones hormone substitutes and hormone antagonists
Zdroj:	Gynecological Endocrinology. 29:793-796
ISSN:	1473-0766 0951-3590
DOI:	10.3109/09513590.2013.801449
Popis:	We have previously hypothesized that early miscarriage in women with Hashimoto thyroiditis might be the result of a cross-reactivity process, in which blocking autoantibodies against thyrotropin receptor (TSHr-Ab) antagonize hCG action on its receptor on the corpus luteum. To test this hypothesis from the clinical perspective, we investigated the presence of TSHr-Ab in Hashimoto thyroiditis patients with apparently unexplained, first-trimester recurrent miscarriages compared to that in Hashimoto thyroiditis patients with documented normal fertility. A total of 86 subjects (43 cases and 43 age-matched controls) were finally included in a case-control study. No difference in the prevalence of TSHr-Ab positivity was detected between cases and controls (Fisher's exact test, p value = 1.00). In patients with recurrent miscarriages, TSHr-Ab concentrations did not predict the number of miscarriages (univariate linear regression, p value = 0.08). These results were robust in sensitivity analyses, including only cases with full investigation or those with three or more miscarriages. We conclude that no role could be advocated for TSHr-Ab in the aetiology of recurrent miscarriages in women with Hashimoto thyroiditis.
Databáze:	OpenAIRE
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