Heartland Virus-Associated Death in Tennessee
| Autor: | Cynthia R. Fata, Roger S. Nasci, Julu Bhatnagar, Dianna M. Blau, Sherif R. Zaki, Atis Muehlenbachs, Jason O. Velez, Mohana Karlekar, Christopher D. Paddock, Amy J. Lambert, J. Erin Staples |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Phlebovirus Microbiology (medical) Autopsy Disease Article Virus Pulmonary Disease Chronic Obstructive Fatal Outcome Risk Factors medicine Humans Serotyping Aged 80 and over Tick-borne disease Leukopenia biology business.industry medicine.disease biology.organism_classification Tennessee Virology Heartland virus Phlebotomus Fever Infectious Diseases Immunology Ehrlichiosis (canine) medicine.symptom business |
| Zdroj: | Clinical Infectious Diseases. 59:845-850 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1093/cid/ciu434 |
| Popis: | Background Heartland virus (HRTV) is a tick-borne phlebovirus recently described in Missouri that is associated with fever, leukopenia, and thrombocytopenia. The virus has also been detected in Ambylomma americanum ticks. Methods Here we report the first fatal case of HRTV disease in an 80-year-old Tennessee resident. He was hospitalized with fever, confusion, leukopenia, and thrombocytopenia and developed multiorgan failure and hemorrhage. A tick-borne illness was suspected and testing for ehrlichiosis was negative. He died on hospital day 15, and autopsy specimens were tested for various pathogens as part of an unexplained death evaluation. Results HRTV antigens were detected in postmortem spleen and lymph nodes by immunohistochemistry, and HRTV was detected in premortem blood by reverse transcription polymerase chain reaction and by isolation in cell culture. Conclusions This case demonstrates that HRTV infection can cause severe disease and death and expands the geographic range of HRTV within the United States. |
| Databáze: | OpenAIRE |
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