Utility of osteoporosis self-assessment tool as a screening tool for osteoporosis in Irish men and women: Results of the DXA-HIP project
| Autor: | Attracta Brennan, Lan Yang, Miriam O'Sullivan, Aoife McPartland, Ming Yu, Erjiang E, Tingyan Wang, Bridie Rooney, Bryan Whelan, Mary Dempsey, Gráinne O'Malley, C. Silke, Wing P. Chan, John J. Carey |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine Gerontology Self-assessment Self-Assessment Endocrinology Diabetes and Metabolism Population Osteoporosis 030209 endocrinology & metabolism 03 medical and health sciences Absorptiometry Photon 0302 clinical medicine Irish Bone Density BMD Humans Medicine Radiology Nuclear Medicine and imaging Orthopedics and Sports Medicine Screening tool education Aged Femoral neck DXA education.field_of_study Lumbar Vertebrae Proximal femur business.industry Middle Aged medicine.disease language.human_language medicine.anatomical_structure language Population study Osteoporosis Self-assessment Tool Female 030101 anatomy & morphology business Ireland |
| Popis: | Many algorithms have been developed and publicised over the past 2 decades for identifying those most likely to have osteoporosis or low BMD, or at increased risk of fragility fracture. The Osteoporosis Self-assessment Tool index (OSTi) is one of the oldest, simplest, and widely used for identifying men and women with low BMD or osteoporosis. OSTi has been validated in many cohorts worldwide but large studies with robust analyses evaluating this or other algorithms in adult populations residing in the Republic of Ireland are lacking, where waiting times for public DXA facilities are long. In this study we evaluated the validity of OSTi in men and women drawn from a sampling frame of more than 36,000 patients scanned at one of 3 centres in the West of Ireland. 18,670 men and women aged 40 years and older had a baseline scan of the lumbar spine femoral neck and total hip available for analysis. 15,964 (86%) were female, 5,343 (29%) had no major clinical risk factors other than age, while 5,093 (27%) had a prior fracture. Approximately 2/3 had a T-score ¿-1.0 at one or more skeletal sites and 1/3 had a T-score ¿-1.0 at all 3 skeletal sites, while 1 in 5 had a DXA T-score ¿-2.5 at one or more skeletal sites and 5% had a T-score ¿-2.5 at all 3 sites. OSTi generally performed well in our population with area under the curve (AUC) values ranging from 0.581 to 0.881 in men and 0.701 to 0.911 in women. The performance of OSTi appeared robust across multiple sub-group analyses. AUC values were greater for women, proximal femur sites, those without prior fractures and those not taking osteoporosis medication. Optimal OSTi cut-points were '2' for men and '0' for women in our study population. OSTi is a simple and effective tool to aid identification of Irish men and women with low BMD or osteoporosis. Use of OSTi could improve the effectiveness of DXA screening programmes for older adults in Ireland. peer-reviewed 2022-03-03 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|