Nitric oxide synthesis is involved in arterial haptoglobin expression after sustained flow changes
| Autor: | Ben van Middelaar, Mirjam B. Smeets, Dominique P.V. de Kleijn, Sai-Kiang Lim, Gerard Pasterkamp, Evelyn Velema |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Biophysics Nitric Oxide Biochemistry Nitric oxide chemistry.chemical_compound Mice Structural Biology Internal medicine polycyclic compounds Genetics medicine Arterial remodeling Animals skin and connective tissue diseases Molecular Biology DNA Primers Mice Knockout Nitric oxide synthesis biology Base Sequence Haptoglobins Interleukin-6 Haptoglobin Acute-phase protein Flow change food and beverages Cell Biology Arteries Endocrinology medicine.anatomical_structure NG-Nitroarginine Methyl Ester chemistry Regional Blood Flow Knockout mouse biology.protein Rabbits Artery |
| Zdroj: | FEBS letters. 529(2-3) |
| ISSN: | 0014-5793 |
| Popis: | The acute phase protein haptoglobin is highly expressed in arteries after sustained flow changes and involved in cell migration and arterial restructuring. In the liver, haptoglobin expression is mainly regulated by interleukin-6 (IL-6). In the artery, shear stress and NO influence IL-6 expression. In the present study, we demonstrate that NO synthesis is involved in the regulation of arterial haptoglobin expression after sustained flow changes. Decreased haptoglobin expression after NO inhibition coincided with decreased IL-6 levels. However, IL-6 knockout mice had normal arterial haptoglobin expression levels after sustained flow changes suggesting that other mediators may provide compensatory mechanisms for the regulation of arterial haptoglobin expression. |
| Databáze: | OpenAIRE |
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