Risk of skin cancer in patients on chronic haemodialysis: a nationwide, population-based study in Taiwan
| Autor: | Chia Chen Wang, Chao-Hsiun Tang, Yuh-Mou Sue, Siao Yuan Huang, C. Y. Wang |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Skin Neoplasms Population 030232 urology & nephrology Taiwan Dermatology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Age Distribution Renal Dialysis Risk Factors medicine Humans education Melanoma Aged education.field_of_study business.industry Incidence (epidemiology) Cancer Retrospective cohort study Middle Aged medicine.disease Confidence interval Surgery Case-Control Studies Cohort Cutaneous melanoma Chronic Disease Female Skin cancer business |
| Zdroj: | The British journal of dermatology. 175(6) |
| ISSN: | 1365-2133 |
| Popis: | SummaryBackground Patients on chronic haemodialysis (HD) have a higher incidence of cancer. However, the risk of skin cancer in this population has rarely been investigated. Objectives To investigate the risk of nonmelanoma skin cancer (NMSC) and cutaneous melanoma in patients on chronic HD and to explore the associated risk factors. Methods We performed retrospective cohort and nested case–control studies using records in the Taiwanese National Health Insurance Research Database between 1999 and 2013. The HD cohort included 79 668 incident patients on HD, for whom the standardized incidence ratios (SIRs) for incident NMSC and cutaneous melanoma were determined. In the nested case–control study, patients on HD with NMSC were matched to those without skin cancers. The impact of various factors on the development of NMSC was determined by conditional logistic regression analysis. Results Among the 79 668 patients on HD, 248 cases of NMSC and 22 cases of cutaneous melanoma occurred after a mean 4·95 years of follow-up. The SIRs for NMSC and cutaneous melanoma in patients on HD were 1·58 (95% confidence interval 1·39–1·79) and 1·44 (95% confidence interval 0·91–2·19), respectively. Of the patients on HD, a higher risk of NMSC was found in men (1·5-fold), South Taiwan residents (twofold) and patients with uraemic pruritus after long-term antihistamine treatment (1·53-fold). However, the incidence of NMSC was not increased in patients with uraemic pruritus receiving ultraviolet B phototherapy. Conclusions Patients on chronic HD are at higher risk of NMSC. Uraemic pruritus further increases the risk of NMSC, which might be prevented by ultraviolet B phototherapy. |
| Databáze: | OpenAIRE |
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