Phytochemical, antioxidant and protective effect of cactus cladodes extract against lithium-induced liver injury in rats

Autor: Brahmi Dalel, Anouar Ben Saad, Sana Ncib, Amani Smida, Lazhar Zourgui, Ilhem Rjeibi, Nacim Zouari
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Antioxidant
medicine.medical_treatment
Phytochemicals
Pharmaceutical Science
medicine.disease_cause
Antioxidants
chemistry.chemical_compound
0302 clinical medicine
Liver Function Tests
Drug Discovery
Spectroscopy
Fourier Transform Infrared
oxidative stress
Chromatography
High Pressure Liquid
Chelating Agents
Liver injury
biology
Traditional medicine
Chemistry
Opuntia
General Medicine
Phytochemical
Biochemistry
Distilled water
Liver
030220 oncology & carcinogenesis
Cactus
histopathology
Molecular Medicine
Chemical and Drug Induced Liver Injury
03 medical and health sciences
Lithium Carbonate
Cladodes
medicine
Animals
Rats
Wistar
alkali metal
Pharmacology
Plants
Medicinal
Plant Extracts
Lithium carbonate
lcsh:RM1-950
biology.organism_classification
medicine.disease
Disease Models
Animal
030104 developmental biology
lcsh:Therapeutics. Pharmacology
Complementary and alternative medicine
Cytoprotection
liver damage
Lipid Peroxidation
Oxidative stress
Biomarkers
Phytotherapy
Zdroj: Pharmaceutical Biology, Vol 55, Iss 1, Pp 516-525 (2017)
Scopus-Elsevier
ISSN: 1744-5116
1388-0209
Popis: Context: Opuntia ficus-indica (L.) Mill. (Castaceae) (cactus) is used in Tunisian medicine for the treatment of various diseases. Objective: This study determines phytochemical composition of cactus cladode extract (CCE). It also investigates antioxidant activity and hepatoprotective potential of CCE against lithium carbonate (Li2CO3)-induced liver injury in rats. Materials and methods: Twenty-four Wistar male rats were divided into four groups of six each: a control group given distilled water (0.5 mL/100 g b.w.; i.p.), a group injected with Li2CO3 (25 mg/kg b.w.; i.p.; corresponding to 30% of the LD50) twice daily for 30 days, a group receiving only CCE at 100 mg/kg of b.w. for 60 days and then injected with distilled water during the last 30 days of CCE treatment, and a group receiving CCE and then injected with Li2CO3 during the last 30 days of CCE treatment. The bioactive components containing the CCE were identified using chemical assays. Results: Treatment with Li2CO3 caused a significant change of some haematological parameters including red blood cells (RBC), white blood cells (WBC), haemoglobin content (Hb), haematocrit (Ht) and mean corpuscular volume (VCM) compared to the control group. Moreover, significant increases in the levels of glucose, cholesterol, triglycerides and of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) activities were observed in the blood of Li2CO3-treated rats. Furthermore, exposure to Li2CO3 significantly increased the LPO level and decreased superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities in the hepatic tissues. Conclusion: CCE possesses a significant hepatoprotective effect.
Databáze: OpenAIRE
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